Abstract:
The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective
study was performed on 2 groups of dogs undergoing either ovariohysterectomy or
hemilaminectomy. The serum activity of creatine kinase and serum concentration of
C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours
postoperatively in both groups. The results were compared statistically both within and
between the 2 groups. A wide range of results was found at each time point for both
analytes although there were no significant differences for either analyte between the
2 surgical groups preoperatively. Thereafter there were significant differences in creatine
kinase activity levels between the 2 groups. C-reactive protein concentration results were
very similar in the 2 groups with no statistical difference at any time point. The results of this
study suggest that the evaluation of CK and CRP at any one time point in a traumatised
animal is of limited value. However, the evaluation of the trend of these 2 analytes, even
over a relatively short time period, may allow for useful prognostication in clinical cases.
