Proposed histological progression of the Spirocerca lupi-induced oesophageal lesion in dogs

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dc.contributor.author Dvir, Eran
dc.contributor.author Clift, Sarah Jane
dc.contributor.author Williams, Mark C.
dc.date.accessioned 2010-05-26T07:45:36Z
dc.date.available 2010-05-26T07:45:36Z
dc.date.issued 2010-02
dc.description.abstract This study aims to outline the histological progression of the Spirocerca lupi nodule from infection to neoplastic transformation. Sixty-two spirocercosis-induced nodules, 42 non-neoplastic and 20 neoplastic, were stained with HE. Ten non-overlapping high power fields per nodule were examined and non-neoplastic and neoplastic nodules were compared. Inflammation was scored 0–3 and revealed a score of 1.91 ± 0.52 in the non-neoplastic and 0.97 ± 0.5 in the neoplastic cases (p < 0.01). In most non-neoplastic cases the inflammatory infiltrate was lymphoplasmacytic and in the neoplastic cases neutrophils predominated. Necrosis was scored 0–3 and revealed a score of 0.88 ± 0.41 in the non-neoplastic and 1.47 ± 0.5 in the neoplastic cases (p < 0.01). The average number of mitoses over 10 high power fields per nodule was 1.31 ± 1.55 in the non-neoplastic compared to 42.85 ± 30.79 in the neoplastic cases (p < 0.01). The average number of multinucleated giant cells over 10 high power fields per nodule was 0.9 ± 1.45 in the non-neoplastic compared to 13.9 ± 14.66 in the neoplastic cases (p < 0.01). In the non-neoplastic cases, collagen, immature fibroblasts and fibroblast activation (excessively plump euchromatic nuclei with single or multiple prominent nucleoli) were scored 0–3 and a combined score, fibroblasts + activation score − collagen was calculated. The non-neoplastic cases were divided into a combined score of ≤1 (n = 15) or >1 (n = 27). The 2 groups had similar scores for inflammation and necrosis, but were significantly different (p < 0.01) in mitotic index (0.26 ± 0.46 vs. 1.89 ± 1.65) and number of multinucleated cells (0 vs. 1.4 ± 1.6). These results indicate 2 stages in the non-neoplastic nodules: early inflammation, characterized by fibrocytes and abundant collagen, and a pre-neoplastic stage, characterized by activated fibroblasts and reduced collagen. en
dc.identifier.citation Dvir, E, Clift, SJ & Williams, MC 2009, 'Proposed histological progression of the Spirocerca lupi-induced oesophageal lesion in dogs', Veterinary Parasitology, vol. 168, no. 1-2, pp. 71-77. [http://www.sciencedirect.com/science/journal/03044017] en
dc.identifier.issn 0304-4017
dc.identifier.other 10.1016/j.vetpar.2009.10.023
dc.identifier.other 7004445917
dc.identifier.uri http://hdl.handle.net/2263/14127
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Spirocercosis en
dc.subject Fibrosarcoma en
dc.subject Osteosarcoma en
dc.subject Undifferentiated sarcoma en
dc.subject Oesophageal nodules en
dc.subject.lcsh Osteosarcoma -- South Africa en
dc.subject.lcsh Veterinary histopathology en
dc.subject.lcsh Dogs -- Histology en
dc.title Proposed histological progression of the Spirocerca lupi-induced oesophageal lesion in dogs en
dc.type Postprint Article en


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