Abstract:
7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis
A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for
the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity
against Mycobacterium tuberculosis. Despite its potential therapeutic benefits, 7-MJ has demonstrated
in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about
its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of
poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to
decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound.
