Pharmacological control of neutrophil-mediated inflammation : strategies targeting calcium handling by activated polymorphonuclear leukocytes

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dc.contributor.author Tintinger, Gregory Ronald
dc.contributor.author Steel, Helen C.
dc.contributor.author Theron, Annette J.
dc.contributor.author Anderson, Ronald
dc.date.accessioned 2009-05-25T08:37:02Z
dc.date.available 2009-05-25T08:37:02Z
dc.date.issued 2008
dc.description.abstract Unlike most other effector cells of the innate, as well as the adaptive immune systems, the neutrophil is a relatively undiscerning aggressor with scant regard for damage limitation. Although this highly combative, professional phagocyte has become increasingly implicated in the immunopathogenesis of many acute and chronic infl ammatory disorders, of both infective and noninfective origin, effective pharmacological strategies to counter neutrophil aggression have remained elusive. Activation of neutrophils results in rapid mobilization of both stored and extracellular Ca2+, resulting in abrupt, usually transient increases in cytosolic Ca2+, which precede, and are a prerequisite for activation of the Ca2+-dependent pro-infl ammatory activities of these cells. Mobilization of Ca2+ by, and restoration of Ca2+ homeostasis to activated neutrophils are multistep processes which present a number of potential targets, some well recognized and others novel and unconventional, for the pharmacological control of neutrophil-mediated infl ammation. Uncovering these targets represents the primary focus of this review. en_US
dc.identifier.citation Tintinger, GR, Steel, HC, Theron, AJ & Anderson, R 2008, 'Pharmacological control of neutrophil-mediated inflammation : strategies targeting calcium handling by activated polymorphonuclear leukocytes', Drug Design, Development and Therapy, vol. 2, pp. 95-104. [http://www.dovepress.com/drug-design-development-and-therapy-journal] en_US
dc.identifier.issn 1177-8881
dc.identifier.uri http://hdl.handle.net/2263/10102
dc.language.iso en en_US
dc.publisher Dove Medical Press en_US
dc.rights Dove Medical Press en_US
dc.subject Calcium en_US
dc.subject Cyclic AMP en_US
dc.subject NADPH oxidase en_US
dc.subject Neutrophils en_US
dc.subject Sodium-calcium exchanger en_US
dc.subject.lcsh Neutrophils
dc.subject.lcsh Cyclic adenylic acid
dc.subject.lcsh Pharmacology
dc.subject.lcsh Calcium
dc.title Pharmacological control of neutrophil-mediated inflammation : strategies targeting calcium handling by activated polymorphonuclear leukocytes en_US
dc.type Article en_US


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