Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals
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| dc.contributor.author | Mistry, Priyal
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| dc.contributor.author | Potgieter, Joachim
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| dc.contributor.author | Pepper, Michael Sean
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| dc.contributor.author | Durandt, Chrisna
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| dc.date.accessioned | 2025-02-06T06:46:37Z | |
| dc.date.issued | 2025 | |
| dc.description | DATA AVAILABILITY : Data is available from the corresponding author upon reasonable request. | en_US |
| dc.description.abstract | Human immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV-1 infections are concentrated. People living with HIV (PLWH) often present with haematological abnormalities including alterations of the bone marrow (BM; dysplasia and cellularity changes) and most commonly cytopenias (anaemia, thrombocytopenia and neutropenia). From these clinical observations it is clear that HIV not only impacts the immune system but also the broader haematopoietic system. The underlying cause of HIV-mediated changes in the haematological system remains complex and multifactorial. | en_US |
| dc.description.department | Haematology | en_US |
| dc.description.department | Immunology | en_US |
| dc.description.embargo | 2026-01-21 | |
| dc.description.librarian | hj2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | A National Health Laboratory Service (NHLS) Research Trust Award, the South African Medical Research Council (SAMRC) Extramural Unit for Stem Cell Research and Therapy, the University of Pretoria via the Institute for Cellular and Molecular Medicine and the National Research Foundation (NRF) Postgraduate Scholarship. | en_US |
| dc.description.uri | https://link.springer.com/journal/12015 | en_US |
| dc.identifier.citation | Mistry, P., Potgieter, J.J.C., Pepper, M.S. et al. Phenotypic Characterisation of Bone Marrow-Derived Haematopoietic Stem/Progenitor Cells from HIV-Infected Individuals. Stem Cell Reviews and Reports (2025). https://doi.org/10.1007/s12015-024-10834-z. | en_US |
| dc.identifier.issn | 1550-8943 (print) | |
| dc.identifier.issn | 1558-6804 (online) | |
| dc.identifier.other | 10.1007/s12015-024-10834-z | |
| dc.identifier.uri | http://hdl.handle.net/2263/100559 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.rights | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. The original publication is available at : http://link.springer.comjournal/12015. | en_US |
| dc.subject | Human immunodeficiency virus (HIV) | en_US |
| dc.subject | People living with HIV (PLHIV) | en_US |
| dc.subject | Sub-Saharan Africa (SSA) | en_US |
| dc.subject | Letter | en_US |
| dc.subject | Bone marrow | en_US |
| dc.subject | Haematopoietic stem cells (HSCs) | en_US |
| dc.subject | Haematopoietic stem and progenitor cells (HSPCs) | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals | en_US |
| dc.type | Postprint Article | en_US |
