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Browsing by UP Author "Visagie, M.H. (Michelle Helen)"
Now showing items 1-20 of 32
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17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (Wiley, 2014)Microtubules are important targets when studying potential anticancer agents since disturbance of these microtubule dynamics results in cell cycle arrest and cell death. 2-Methoxyestradiol is a naturally occurring metabolite ...
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Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (BioMed Central, 2015-04-22)INTRODUCTION : Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Springer, 2011-11)In anticancer research where the focus is on finding agents that induces cell death while leaving nontumorigenic cells less affected, a novel 2-methoxyestradiol derivative has come forth. 2-Methoxyestradiol-bis-sulfam ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (BioMed Central, 2012-08-20)BACKGROUND: Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic ...
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Janse van Vuuren, Rustelle; Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Joubert, Annie M. (SpringerOpen, 2015-12)Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that ...
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Gomes, D.A.; Joubert, Anna Margaret; Visagie, M.H. (Michelle Helen) (MDPI, 2022-10-26)Papaverine (PPV), a benzylisoquinoline alkaloid, extracted from the Papaverine somniferum plant, is currently in clinical use as a vasodilator. Research has shown that PPV inhibits phosphodiesterase 10A (PDE10A,) resulting ...
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Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M. (Public Library of Science, 2017-04-14)Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R, 13S,14S,17S)-2-ethyl-13-methyl- ...
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Verwey, M.; Joubert, Annie M.; Visagie, M.H. (Michelle Helen); Annie M.; Theron, A.E. (Biomedical Research Press, 2016)Breast cancer is the most prevalent cancer in women worldwide, contributing to 14% of all new cancer cases and 6.8% of all cancer deaths in 2014. A new area of cancer research has arisen from the discovery of cancer ...
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Reva, Oleg N.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Klochko, Vitalii V.; Joubert, Anna Margaretha; Lall, Namrita (Future Science, 2019)AIM : To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. MATERIALS AND METHODS : Molecular docking, cytotoxicity ...
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Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (BioMed Central, 2018-05-04)Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ...
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Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Albrecht, C.; Joubert, Annie M. (Elsevier, 2014-01)Sutherlandia frutescens (SF) is a traditional Africanmedicinal aid employed for the treatment of various ailments such as inflammation, pulmonary asthma and congestion. The present study was conducted to demonstrate ...
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Lebelo, M.T. (Maphuti); Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (MDPI, 2021-01-25)Recent findings revealed that 2-ethyl-17-oxoestra-1,3,5(10)-trien-3-yl sulfamate (ESE-one) induces antiproliferative activity and cell rounding dependent on the generation of superoxide anion, hydrogen peroxide and peroxyl ...
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Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (BioMed Central, 2019-03-27)BACKGROUND : Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivation ...
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Visagie, M.H. (Michelle Helen); Jaiswal, Seema Rummurat; Joubert, Annie M. (BioMed Central, 2016-11-02)BACKGROUND : Computer-based technology is becoming increasingly essential in biological research where drug discovery programs start with the identification of suitable drug targets. 2-Methoxyestradiol (2ME2) is a ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Springer, 2010-12)2-methoxyestradiol (2ME2) exerts estrogen receptor independent antiproliferative, antiangiogenic and antitumor activity in vitro and in vivo. Due low bioavailability and fast metabolic degradation, several analogues have ...
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Gomes, Daniella Anthea de Agrela; Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (MDPI, 2021-10-22)Papaverine (PPV) is an alkaloid isolated from the Papaver somniferum. Research has shown that PPV inhibits proliferation. However, several questions remain regarding the effects of PPV in tumorigenic cells. In this study, ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)This study indicates that 2-methoxyestradiol-bissulphamate induces both apoptosis and autophagy and contributes to the unraveling of the action mechanism of 2-methoxyestradiol-bis-sulphamate.
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Mathews, Edward Henry; Visagie, M.H. (Michelle Helen); Meyer, Albertus Abram; Joubert, Anna Margaretha; Mathews, George Edward (Elsevier, 2020-06)OBJECTIVE : Although metabolic treatment of highly glycolytic cancers and metastases is becoming an important research field, the effects of such treatments are not fully quantified yet. In this article we attempt to ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (AOSIS Open Journals, 2013)2-Methoxyestradiol-bissulphamate shows therapeutic potential, however, the exact mechanism of action remains elusive. Data obtained from this study contributes to the embedded scientific knowledge regarding the signalling ...
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Nkandeu, Sandra; Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Marais, Sumari; Stander, Barend A.; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)After a 24 hour exposure time, cells both apoptosis and autophagy were induced.
Now showing items 1-20 of 32