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Browsing by UP Author "Stander, Barend Andre"
Now showing items 1-20 of 20
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Marais, Sumari; Stander, Barend Andre; Joubert, Annie M. (AOSIS Open Journals, 2013)2-MEBM induced apoptosis and autophagy in HeLa cells and also disrupted the cellular microtubule network. This contributes to the understanding of the in vitro mechanism of action of 2MEBM as a potential anticancer drug.
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Fraser, Desiree Linda; Stander, Barend Andre; Steenkamp, Vanessa (Elsevier, 2019-08)As knowledge regarding mechanisms of pentachlorophenol (PCP) toxicity in neuronal cell lines is limited, the aim of the study was to evaluate the effects of PCP and its active metabolites, tetrachloro-1,4-benzoquinone ...
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Stander, Barend Andre; Marais, Sumari; Huyser, Carin; Fourie, Zen; Leszczynski, Dariusz; Joubert, Annie M. (Academy of Science of South Africa, 2011-09-14)Mobile phone usage currently exceeds landline communication in Africa. The extent of this usage has raised concerns about the long-term health effects of the ongoing use of mobile phones. To assess the physiological effects ...
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Manilall, Ashmeetha; Stander, Barend Andre; Madziva, Michael Taurai; Millar, Robert P.; Flanagan, Colleen A. (Elsevier, 2019-02)Please read abstract in the article.
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An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles Stander, Barend Andre; Van Vollenstee, Fiona A.; Kallmeyer, Karlien; Potgieter, Marnie; Joubert, Annie M.; Swanepoel, Andri; Kotze, Lara; Moolman, Sean; Pepper, Michael Sean (Public Library of Science, 2018-07-03)The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and ...
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Nkandeu, Danielle Sandra; Mqoco, Thandi Vuyelwa; Visagie, Michelle Helen; Stander, Barend Andre; Wolmarans, Elize; Cronje, Marianne J.; Joubert, Annie M. (Wiley, 2013-10)2-Methoxyestradiol, a natural metabolite of estradiol, exerts antiproliferative and antitumour properties in vitro and in vivo. Because of its low oral bioavailability, several promising analogues of 2-methoxyestradiol ...
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Stander, Xiao Xing; Stander, Barend Andre; Joubert, Annie M. (Wiley-Blackwell, 2011-12)OBJECTIVES : To investigate anti-proliferative properties of a novel in silico-modelled 17β-oestradiol derivative (C9), in combination with dichloroacetic acid (DCA), on MCF-7 and MCF-12A cells. MATERIALS AND METHODS : ...
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Stander, Barend Andre; Joubert, Fourie; Joubert, Annie M.; Theron, D.; Albrecht, C.; Creative Studios, Dept. of Education Innovation (2008-10-21)Sutherlandia frutescens is a South African herbal remedy traditionally used for stomach problems, diabetes and lately to improve the overall health in cancer and HIV/AIDS patients. The in vitro influence of crude S. ...
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Marais, Sumari; Mqoco, T.V. (Thandi Vuyelwa); Stander, Barend Andre; Prudent, Renaud; Lafanechere, Laurence; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)It can be concluded that compound-X induced both autophagy and apoptosis as a means of cell death in HeLa cells.
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Stander, Barend Andre; Joubert, Fourie; Joubert, Annie M. (AOSIS Open Journals, 2013)This study contributes to the understanding of molecular mechanisms and cell signaling events associated with in vitro anticancer responses of a new and novel antimitotic compound, 2-etiel-3-sulfamaat- 1,3,5(10)16-tetraeen ...
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Stander, Barend Andre; Joubert, Fourie; Tu, Chingkuang; Sippel, Katherine H.; McKenna, Robert; Joubert, Annie M.; Ahmad, Aamir (Public Library of Science, 2012-12)Antimitotic compounds are still one of the most widely used chemotherapeutic anticancer drugs in the clinic today. Given their effectiveness against cancer it is beneficial to continue enhancing these drugs. One way is ...
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Stander, Barend Andre; Marais, Sumari; Vorster, C.J.J. (Christiaan Jacob Johan); Joubert, Annie M. (Elsevier, 2010-04)In the present study, the antiproliferative mechanism of action of 1 M 2-methoxyestradiol (2ME) was investigated in the MCF-7 cell line. Measurement of intracellular cyclin B and cytochrome c protein levels, reactive ...
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Marais, Sumari; Stander, Barend Andre; Huyser, Carin; Joubert, Annie M.; Le Roux, Fourie; Leszczynski, Dariusz; Creative Studios, Dept of Education Innovation, University of Pretoria (2008-11-12)Mobile phones and other hand-held type transceivers are widely used in the world and their utilization currently exceeds landline communication in Africa. This has raised concerns about the long-term health effects of their ...
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Stander, Barend Andre; Marais, Sumari; Steynberg, Tenille Jolene; Theron, D.; Joubert, Fourie; Albrecht, C.; Joubert, Annie M. (Elsevier, 2007-06-13)Sutherlandia frutescens is a well-known South African herbal remedy traditionally used for stomach problems, internal cancers, diabetes, various inflammatory conditions and recently to improve the overall health in cancer ...
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Stander, Barend Andre; Joubert, Fourie; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)The importance of these results will aid the development of treatments of cancer targeted at specific pathways associated with specific cancers.
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Visagie, M.H. (Michelle Helen); Stander, Barend Andre; Birkholtz, Lyn-Marie; Joubert, Annie M. (Biomedical Research Press, 2013)2-Methoxyestradiol is a 17-beta estradiol derivative with antitumor activity. Due to low bioavailability, a new estrogen analogue was in silico-designed. The latter, a sulphamoylated analogue of 2-methoxyestradiol, was ...
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Stander, Barend Andre; Joubert, Fourie; Tu, Chingkuang; Sippel, Katherine H.; McKenna, Robert; Joubert, Annie M. (Public Library of Science, 2013-01-31)The aim of this study was to characterize the in vitro action of 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) on non-tumorigenic MCF-12A, tumorigenic MCF-7 and metastatic MDA-MB-231 breast cancer cells. ...
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Stander, Xiao Xing; Stander, Barend Andre; Joubert, Annie M. (Karger, 2015-04)BACKGROUND : C9, a newly in silico-designed inhibitor of microtubule dynamics induces G2/M arrest culminating in apoptosis. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase, an enzyme that promotes pyruvate ...
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Kapp, Nicolette; Stander, Xiao Xing; Stander, Barend Andre (Lippincott, Williams & Wilkins, 2018-06)This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...
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Mathews, Edward Henry; Stander, Barend Andre; Joubert, Annie M.; Liebenberg, Leon (Elsevier, 2014-02)OBJECTIVE : Most glucose (and glutamine)-deprivation studies of cancer cell cultures focus on total depletion, and are conducted over at least 24 h. It is difficult to extrapolate findings from such experiments to practical ...
Now showing items 1-20 of 20