Browsing by UP Author "Pool, Roger"

Browsing by UP Author "Pool, Roger"

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  • Apoptotic profiling of chronic myeloid leukaemia patients' platelets ex vivo before and after treatment with Imatinib 
    Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Becker, Piet J.; Joubert, Anna Margaretha (Wiley, 2021-06)
    Chronic myeloid leukaemia (CML) is a malignancy of the haematopoietic stem cells. The first line of treatment for CML, especially in developing countries, remains the first-generation tyrosine kinase inhibitor, Imatinib. ...
  • Application of the AMLprofiler diagnostic microarray in the South African setting 
    Kappala, S.S.; Alessandrini, Marco; Matlhako, T.; Beltchev, E.; Pool, Roger; Pepper, Michael Sean (Hindawi Publishing Corporation, 2017-11-07)
    Acute myeloid leukemia (AML) is characterized by proliferation of the myeloid lineage and accumulation of immature hematopoietic cells in the bone marrow and is typified by marked heterogeneity both in response to treatment ...
  • Cancer diagnoses profile of bone marrow specimens from November 2012 to December 2015 in a tertiary academic setting 
    Swart, Nicola; Pool, Roger; Prinsloo, Andrea (Society of Medical Laboratory Technologists of South Africa, 2017-06)
    This study aimed to examine the number and type of cancer diagnoses made based on bone marrow aspirates (BMA) using morphology and/or histology, over a three year period. All the data collected (2012-2015) was obtained ...
  • The correlation between C-reactive protein and toxic granulation of neutrophils in the peripheral blood 
    Van de Vyver, Annemarie; Delport, Eluned F.; Esterhuizen, M.; Pool, Roger (Health and Medical Publishing Group, 2010-07)
    BACKGROUND: During inflammation, the serum concentrations of granulocyte colony-stimulating factor (G-CSF), plasma interleukin-6 (IL-6), and C-reactive protein (CRP) increase. A positive correlation between CRP and the ...
  • Discrepant clinical and haematological features in siblings of Pakistani origin with β-thalassaemia 
    Prinsloo, Andrea; Potgieter, Johan J.C.; Moodley, Vanessa; Pool, Roger; Opperman, Johannes; Henderson, Shirley; Old, John (Health and Medical Publishing Group, 2009-05)
    An 8-year-old boy was referred with anaemia and splenomegaly. Physical examination revealed short stature, thalassaemic facies, pallor and splenomegaly. The full blood count showed a hypochromic, microcytic anaemia. The ...
  • An endometrial histomorphometric study of CD56+ natural killer cells in women with unexplained infertility 
    Muller, M.; Kalmeier, G.; Eyal, P.; De Bruin, A.; Pool, Roger; Du Rant, C.; Ehlers, Rene; Stander, Andre; Van Schoor, Albert-Neels; Nortje, Evangeline; Du Toit, Peet J. (Health and Medical Publishing Group, 2017-09)
    BACKGROUND. The number of peripheral blood and endometrial natural killer cells varies greatly during implantation and the first trimester of pregnancy and is thought to play a role in the maintenance of a healthy pregnancy. ...
  • Ex vivo platelet morphology assessment of chronic myeloid leukemia patients before and after Imatinib treatment 
    Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Joubert, Anna Margaretha (Wiley, 2022-06)
    Chronic myeloid leukemia (CML) is a myeloproliferative disease and the first line treatment is through the administration of Imatinib, a first generation tyrosine kinase inhibitor. Thrombocytosis and bleeding irregularities ...
  • Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa 
    Louw, V.J.; Bassa, F.; Chan, S.W.; Dreosti, Lydia M.; Du Toit, M.; Ferreira, M.; Gartrell, K.; Gunther, K.; Jogessar, V.; Littleton, N.; Mahlangu, J.; McDonald, A.; Patel, M.; Pool, Roger; Ruff, P.; Schmidt, A.; Sissolak, G.; Swart, Andre; Verburgh, E.; Webb, M.J. (Health and Medical Publishing Group, 2011-12)
    INTRODUCTION: Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ...
  • The impact of collection tube fill volume on international normalized ratio 
    Potgieter, Johan J.C.; Pool, Roger; Prinsloo, Andrea; Botha, Elsabie M.D.; Olorunju, Steve A.S. (Society of Medical Laboratory Technologists of South Africa, 2010-06)
    INTRODUCTION: Pre-analytical variability currently represents the most important source of errors that can lead to inaccurate patient results in monitoring of patients being treated with oral anticoagulant therapy. The ...
  • The impact of collective tube fill volume on international normalised ratio 
    Potgieter, Johan J.C.; Olorunju, Steve A.S.; Pool, Roger; Botha, E.; Prinsloo, Andrea; Creative Studios (2008-09-17)
    Pre-analytical variability currently represents the most important source of errors that can lead to inaccurate laboratory results in monitoring of patients being treated with oral anticoagulant therapy. The volume of blood ...
  • Low-secretory multiple myeloma 
    Visser, Hilgaard Frans; Visser, Adele; Nel, J.M.; Moodley, Vanessa; Swart, Andre; Pool, Roger (South African Orthopaedic Association / Char Publications, 2009)
    Multiple myeloma (MM) is an incurable malignancy arising from postgerminal B lymphocytes. It is estimated to account for 10-15% of haematological malignancies and 1% of all malignancies. Non-secretory multiple myeloma ...
  • Neutrophil extracellular traps and their role in health and disease 
    Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)
    The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
  • An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia 
    Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Joubert, Annie M. (BioMed Central, 2017-10-10)
    Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
  • Pneumolysin activates neutrophil extracellular trap formation 
    Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)
    The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
  • Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Theron, Annette J.; Tintinger, Gregory Ronald; Pool, Roger; Richards, Guy A.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2017-06)
    OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the ...
  • Retrospective data analysis of all requests for flow cytometric immunophenotyping in a tertiary hospital setting 
    Prinsloo, Andrea; Nel, Jan Gert; Pool, Roger (Society of Medical Laboratory Technologists of South Africa, 2017-06)
    Flow cytometry is a globally accepted diagnostic tool used for the rapid identification of cells based on their surface and intracellular antigens, especially for the diagnosis of haematological malignancies. The aim of ...
  • Retrospective review of multiple myeloma and immunosecretory disorder cases diagnosed in a tertiary setting 
    Visser, Hilgaard Frans; Visser, Adele; Snyckers, Christian Hugo; Goller, Ruan; Pool, Roger; Myburgh, Jan G. (South African Orthopaedic Association / Char Publications, 2009)
    PURPOSE OF THE STUDY: Despite the relatively high incidence of multiple myeloma reported worldwide, South African statistics seem to be significantly lower. Our purpose in doing this study was to determine whether patients ...