Browsing by UP Author "Mayaphi, Simnikiwe Horatious"

Browsing by UP Author "Mayaphi, Simnikiwe Horatious"

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  • Antenatal screening for hepatitis B virus in HIV-infected and uninfected pregnant women in the Tshwane district of South Africa 
    Diale, Q.; Pattinson, Robert Clive; Chokoe, R.; Masenyetse, L.; Mayaphi, Simnikiwe Horatious (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. Despite enormous strides in preventing hepatitis B virus (HBV) infection, perinatal transmission still contributes significantly to HBV epidemiology worldwide; this could account for approximately 50% of ...
  • Cytomegalovirus viral load kinetics in patients with HIV/AIDS admitted to a medical intensive care unit : a case for pre-emptive therapy 
    Mayaphi, Simnikiwe Horatious; Brauer, Marieke; Morobadi, Daniel M.; Mazanderani, Ahmad Haeri; Mafuyeka, Rendani T.; Olorunju, Steve A.S.; Tintinger, Gregory Ronald; Stoltz, Anton Carel (Public Library of Science, 2014-04-03)
    BACKGROUND : Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there is a lack of data for pre-emptive therapy in patients with HIV/AIDS. METHOD : This was a ...
  • Deep sequencing of the HIV‑1 polymerase gene for characterisation of cytotoxic T‑lymphocyte epitopes during early and chronic disease stages 
    Nkone, Paballo; Loubser, Shayne; Quinn, Thomas C.; Redd, Andrew D.; Ismail, Arshad; Tiemessen, Caroline T.; Mayaphi, Simnikiwe Horatious (BMC, 2022-03)
    BACKGROUND : Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (pol) gene is highly conserved and encodes cytotoxic T-lymphocyte (CTL) epitopes. The aim of the study was ...
  • Detection of acute and early HIV-1 infections in an HIV hyper-endemic area with limited resources 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Quinn, Thomas C.; Laeyendecker, Oliver; Olorunju, Steve A.S.; Tintinger, Gregory Ronald; Stoltz, Anton Carel (Public Library of Science, 2016-10-20)
    BACKGROUND: Two thirds of the world's new HIV infections are in sub-Saharan Africa. Acute HIV infection (AHI) is the time of virus acquisition until the appearance of HIV antibodies. Early HIV infection, which includes ...
  • Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 
    Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)
    A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
  • Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa 
    Tegally, Houriiyah; Moir, Monika; Everatt, Josie; Giovanetti, Marta; Scheepers, Cathrine; Wilkinson, Eduan; Subramoney, Kathleen; Makatini, Zinhle; Moyo, Sikhulile; Amoako, Daniel G.; Baxter, Cheryl; Althaus, Christian L.; Anyaneji, Ugochukwu J.; Kekana, Dikeledi; Viana, Raquel; Giandhari, Jennifer; Lessells, Richard; Maponga, Tongai; Maruapula, Dorcas; Choga, Wonderful; Matshaba, Mogomotsi; Mbulawa, Mpaphi B.; Msomi, Nokukhanya; NGS-SA consortium; Naidoo, Yeshnee; Pillay, Sureshnee; Sanko, Tomasz Janusz; San, James E.; Scott, Lesley; Singh, Lavanya; Magini, Nonkululeko A.; Smith-Lawrence, Pamela; Stevens, Wendy; Dor, Graeme; Tshiabuila, Derek; Wolter, Nicole; Preiser, Wolfgang; Treurnicht, Florette K.; Venter, Marietjie; Chiloane, Georginah; McIntyre, Caitlyn; O’Toole, Aine; Ruis, Christopher; Peacock, Thomas P.; Roemer, Cornelius; Pond, Sergei L. Kosakovsky; Williamson, Carolyn; Pybus, Oliver G.; Bhiman, Jinal N.; Glass, Allison; Martin, Darren P.; Jackson, Ben; Rambaut, Andrew; Laguda-Akingba, Oluwakemi; Gaseitsiwe, Simani; Von Gottberg, Anne; De Oliveira, Tulio; Bester, Armand Phillip; Claassen, Mathilda; Doolabh, Deelan; Mudau, Innocent; Mbhele, Nokuzola; Engelbrecht, Susan; Goedhals, Dominique; Hardie, Diana; Hsiao, Nei-Yuan; Iranzadeh, Arash; Ismail, Arshad; Joseph, Rageema; Maharaj, Arisha; Mahlangu, Boitshoko; Mahlakwane, Kamela; Davis, Ashlyn; Marais, Gert; Mlisana, Koleka; Mnguni, Anele; Mohale, Thabo; Motsatsi, Gerald; Mwangi, Peter; Ntuli, Noxolo; Nyaga, Martin; Olubayo, Luicer; Radibe, Botshelo; Ramphal, Yajna; Ramphal, Upasana; Strasheim, Wilhelmina; Tebeila, Naume; Van Wyk, Stephanie; Wilson, Shannon; Lucaci, Alexander G.; Weaver, Steven; Maharaj, Akhil; Pillay, Yusasha; Davids, Michaela; Mendes, Adriano; Mayaphi, Simnikiwe (Nature Research, 2022-09)
    Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa’s fourth Coronavirus Disease 2019 (COVID-19) wave. We ...
  • Evaluation of the Determine™ fourth generation HIV rapid assay 
    Brauer, Marieke; De Villiers, J.C. (Johanna Corrie); Mayaphi, Simnikiwe Horatious (Elsevier, 2013-04)
    Assays that detect p24 antigen reduce the diagnostic window period of HIV testing. Most point-of-care HIV assays have poor sensitivity to diagnose acute HIV infection as they only detect antibodies against HIV-1 and HIV-2 ...
  • Evaluation of the HIV-1 polymerase gene sequence diversity for prediction of recent HIV-1 infections using Shannon entropy analysis 
    Nkone, Paballo; Loubser, Shayne; Quinn, Thomas C.; Redd, Andrew D.; Laeyendecker, Oliver; Tiemessen, Caroline T.; Mayaphi, Simnikiwe Horatious (MDPI, 2022-07-21)
    HIV-1 incidence is an important parameter for assessing the impact of HIV-1 interventions. The aim of this study was to evaluate HIV-1 polymerase (pol) gene sequence diversity for the prediction of recent HIV-1 infections. ...
  • Field performance of the INSTI HIV‐1/‐2 antibody test in two South African antenatal clinics 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Quinn, Thomas C.; Stoltz, Anton Carel (Wiley, 2019-07)
    This was a prospective study that assessed field performance of the INSTI HIV‐1/‐2 antibody test (INSTI test) in two antenatal clinics in South Africa (SA). INSTI test was evaluated against rapid tests used at these clinics, ...
  • Full Genome Amplification and Quasispecies Reconstruction of the Hepatitis B Virus from Next Generation Sequencing Data 
    Le Clercq, Louis-Stéphane; Bowyer, Sheila M.; Mayaphi, Simnikiwe Horatious (Faculty of Health Sciences, 2014)
    The Hepatitis B Virus (HBV) is a DNA virus that infects most vertebrates and is part of the Hepadnaviridae family. Transmission of HBV occurs through bodily fluids such as blood and sexual contact. HBV targets the liver ...
  • Hand-foot-and-mouth disease caused by coxsackievirus A6 in a patient infected with HIV 
    Mayaphi, Simnikiwe Horatious; Van Zyl, Walda B.; Sono, Tinah; Loots, Donovan P.; Taylor, Maureen B. (MedPharm Publications, 2015)
    Hand, foot and mouth disease (HFMD) is common in children ≤ 5 years of age, and is mainly caused by enterovirus 71 and coxsackievirus A16 (CVA6). A 12-year-old boy on treatment for human immunodeficiency virus (HIV) ...
  • HBV/HIV co-infection : the dynamics of HBV in South African patients with AIDS 
    Mayaphi, Simnikiwe Horatious; Rossouw, Theresa M.; Masemola, Difuro P.; Olorunju, Steve A.S.; Mphahlele, M. Jeffrey; Martin, Desmond J. (Health and Medical Publishing Group, 2012-03)
    OBJECTIVE: As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, and their co-infection requires special management, we aimed to assess the serological and ...
  • Hepatitis B virus infection in post-vaccination South Africa : occult HBV infection and circulating surface gene variants 
    Amponsah-Dacosta, Edina; Lebelo, Ramokone L.; Rakgole, J. Nare; Selabe, Selokela G.; Gededzha, Maemu P.; Mayaphi, Simnikiwe Horatious; Powell, Eleanor A.; Blackard, Jason T.; Mphahlele, M. Jeffrey (Elsevier, 2015-02)
    No abstract available
  • High risk exposure to HIV among sexually active individuals who tested negative on rapid HIV tests in the Tshwane District of South Africa—the importance of behavioural prevention measures 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Olorunju, Steve A.S.; Williams, Brian G.; Quinn, Thomas C.; Stoltz, Anton Carel (Public Library of Science, 2018-02-02)
    OBJECTIVE : To assess the prevalence of HIV risk behaviour among sexually active HIV sero-negative individuals in the Tshwane district of South Africa (SA). METHODS : Demographic and HIV risk behaviour data were collected ...
  • HIV-1/2 differentiation in a South African public laboratory 
    Mafuyeka, Rendani T.; Webber, Lynne M.; Becker, Piet J.; Mayaphi, Simnikiwe Horatious (AOSIS, 2021-03-12)
    BACKGROUND : The human immunodeficiency virus type-2 (HIV-2) prevalence in South Africa (SA) is unknown, however, sporadic cases have been reported. Human immunodeficiency virus -1 and 2 differentiation is not part of ...
  • Low seroprevalence of hepatitis E virus in pregnant women in an urban area near Pretoria, South Africa 
    Simani, Omphile E.; Seipone, Tshegofatso P.; Selabe, Gloria; Seheri, L. Mapaseka; Mphahlele, M.; Mayaphi, Simnikiwe Horatious; Steele, A. Duncan (Elsevier, 2022-03)
    OBJECTIVES : Hepatitis E virus (HEV) infection is a globally neglected health problem with a high burden in resource-poor communities. Pregnant women are at increased risk of complications. This pilot study sought to assess ...
  • Nosocomial outbreak of hepatitis B virus infection in a pediatric hematology and oncology unit in South Africa : epidemiological investigation and measures to prevent further transmission 
    Buchner, Ane; Du Plessis, Nicolette Marie; Reynders, David; Omar, Fareed E.; Mayaphi, Simnikiwe Horatious; Haeri Mazanderani, Ahmad F.; Avenant, Theunis Johannes (Wiley, 2015-11)
    BACKGROUND : Hospital-acquired hepatitis B virus (HBV) infection has been well described and continues to occur worldwide. Recent nosocomial outbreaks have been linked to unsafe injection practices, use of multi-dose vials, ...
  • Pre-treatment minority HIV-1 drug resistance mutations and long term virological outcomes : is prediction possible? 
    Mzingwane, Mayibongwe L.; Tiemessen, C.T.; Richter, Karin Louise; Mayaphi, Simnikiwe Horatious; Hunt, G.; Bowyer, S.M. (BioMed Central, 2016-10-12)
    BACKGROUND : Although the use of highly active antiretroviral therapy in HIV positive individuals has proved to be effective in suppressing the virus to below detection limits of commonly used assays, virological failure ...
  • Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa 
    Viana, Raquel; Moyo, Sikhulile; Amoako, Daniel G.; Tegally, Houriiyah; Scheepers, Cathrine; Althaus, Christian L.; Anyaneji, Ugochukwu J.; Bester, Phillip A.; Boni, Maciej F.; Chand, Mohammed; Choga, Wonderful T.; Colquhoun, Rachel; Davids, Michaela; Deforche, Koen; Doolabh, Deelan; Du Plessis, Louis; Engelbrecht, Susan; Everatt, Josie; Giandhari, Jennifer; Giovanetti, Marta; Hardie, Diana; Hill, Verity; Hsiao, Nei-Yuan; Iranzadeh, Arash; Ismail, Arshad; Joseph, Charity; Joseph, Rageema; Koopile, Legodile; Pond, Sergei L. Kosakovsky; Kraemer, Moritz U.G.; Kuate-Lere, Lesego; Laguda-Akingba, Oluwakemi; Lesetedi-Mafoko, Onalethatha; Lessells, Richard; Lockman, Shahin; Lucaci, Alexander G.; Maharaj, Arisha; Mahlangu, Boitshoko; Maponga, Tongai; Mahlakwane, Kamela; Makatini, Zinhle; Marais, Gert; Maruapula, Dorcas; Masupu, Kereng; Matshaba, Mogomotsi; Mayaphi, Simnikiwe; Mbhele, Nokuzola; Mbulawa, Mpaphi B.; Mendes, Adriano; Mlisana, Koleka; Mnguni, Anele; Mohale, Thabo; Moir, Monika; Moruisi, Kgomotso; Mosepele, Mosepele; Motsatsi, Gerald; Motswaledi, Modisa S.; Mphoyakgosi, Thongbotho; Msomi, Nokukhanya; Mwangi, Peter N.; Naidoo, Yeshnee; Ntuli, Noxolo; Nyaga, Martin; Olubayo, Lucier; Pillay, Sureshnee; Radibe, Botshelo; Ramphal, Yajna; Ramphal, Upasana; San, James E.; Scott, Lesley; Shapiro, Roger; Smith-Lawrence, Pamela; Stevens, Wendy; Strydom, Amy; Subramoney, Kathleen; Tebeila, Naume; Tshiabuila, Derek; Tsui, Joseph; Van Wyk, Stephanie; Weaver, Steven; Wibmer, Constantinos K.; Wilkinson, Eduan; Wolter, Nicole; Zarebski, Alexander E.; Zuze, Boitumelo; Goedhals, Dominique; Preise, Wolfgang; Treurnicht, Florette; Venter, Marietjie; Williamson, Carolyn; Pybus, Oliver G.; Bhiman, Jinal; Glass, Allison; Martin, Darren P.; Rambaut, Andrew; Gaseitsiwe, Simani; Von Gottberg, Anne; De Oliveira, Tulio (Nature Research, 2022-03-24)
    The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) ...
  • Recommendations for the medical evaluation of children prior to adoption in South Africa 
    Haeri Mazanderani, Ahmad F.; Du Plessis, Nicolette Marie; Lumb, J.; Feucht, Ute Dagmar; Myburgh, Marcelle; Mayaphi, Simnikiwe Horatious; Lekalakala, M. Ruth; Swanepoel, De Wet; Georgakis, H.; Avenant, Theunis Johannes (Health and Medical Publishing Group, 2014-08)
    The current legislative framework in South Africa (SA) supports adoption as the preferred form of care for children with inadequate or no parental or family support. There are an estimated 3.8 million orphans in SA, with ...