Browsing by UP Author "Joubert, Fourie"

Browsing by UP Author "Joubert, Fourie"

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  • Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells 
    Joubert, Annie M.; Maritz, Christine; Joubert, Fourie (Biomedical Research Press, 2005-06)
    2-Methoxyestradiol (2ME), an endogenous metabolite of 17Beta-estradiol, has been reported to play an active role in the induction of apoptosis in both proliferating endothelial and cancer cells. Since it has been indicated ...
  • Characterization of carbonic anhydrase isozyme specific inhibition by sulfamated 2-ethylestra compounds 
    Sippel, Katherine H.; Stander, Andre; Tu, Chingkuang; Venkatakrishnan, Balasubramanian; Robbins, Arthur H.; Agbandje-McKenna, Mavis; Joubert, Fourie; Joubert, Annie M.; McKenna, Robert (Bentham Science, 2011-10)
    Sulfamated 2-ethylestra compounds have demonstrated strong anticancer activity, high bioavailability and an ability to bypass liver metabolism by reversibly binding carbonic anhydrase (CA) II in erythrocytes. Another CA ...
  • Comparative analysis of plant carbohydrate active enZymes and their role in xylogenesis 
    Pinard, Desre; Mizrachi, Eshchar; Hefer, Charles Amadeus; Kersting, Anna R.; Joubert, Fourie; Douglas, Carl J.; Mansfield, Shawn D.; Myburg, Alexander Andrew (BioMed Central, 2015-05-22)
    BACKGROUND : Carbohydrate metabolism is a key feature of vascular plant architecture, and is of particular importance in large woody species, where lignocellulosic biomass is responsible for bearing the bulk of the stem and ...
  • Coronavirus host genetics South Africa (COHG-SA) database—a variant database for gene regions associated with SARS-CoV-2 outcomes 
    Barmania, Fatima; Mellet, Juanita; Ryder, Megan A.; Ford, Graeme R.; Herd, Candice L.; Tamuhla, Tsaone; Hendricks, Candice Laverne; Giles, Rachel; Kalua, Thumbiko; Joubert, Fourie; Tiffin, Nicki; Pepper, Michael Sean (Springer nature, 2022-08)
    The SARS-CoV-2 virus is responsible for the COVID-19 global public health emergency, and the disease it causes is highly variable in its clinical presentation. Clinical phenotypes are heterogeneous both in terms of ...
  • Deep learning diagnostics of gray leaf spot in maize under mixed disease field conditions 
    Craze, Hamish A.; Pillay, Nelishia; Joubert, Fourie; Berger, David Kenneth (MDPI, 2022-07-26)
    Maize yields worldwide are limited by foliar diseases that could be fungal, oomycete, bacterial, or viral in origin. Correct disease identification is critical for farmers to apply the correct control measures, such as ...
  • Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics 
    Baichoo, Shakuntala; Souilmi, Yassine; Panji, Sumir; Botha, Gerrit; Meintjes, Ayton; Hazelhurst, Scott; Bendou, Hocine; De Beste, Eugene; Mpangase, Phelelani T.; Souiai, Oussema; Alghali, Mustafa; Yi, Long; O’Connor, Brian D.; Crusoe, Michael; Armstrong, Don; Aron, Shaun; Joubert, Fourie; Ahmed, Azza E.; Mbiyavanga, Mamana; Van Heusden, Peter; Magosi, Lerato E.; Zermeno, Jennie; Mainzer, Liudmila Sergeevna; Fadlelmola, Faisal M.; Jongeneel, C. Victor; Mulder, Nicola (BioMed Central, 2018-11-29)
    BACKGROUND : The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
  • The development of computational biology in South Africa : successes achieved and lessons learnt 
    Mulder, Nicola J.; Christoffels, Alan; De Oliveira, Tulio; Gamieldien, Junaid; Hazelhurst, Scott; Joubert, Fourie; Kumuthini, Judit; Pillay, Che S.; Snoep, Jacky L.; Bishop, Ozlem Tastan; Tiffin, Nicki (Public Library of Science, 2016-02-04)
    Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and ...
  • Discovery : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria 
    Joubert, Fourie; Harrison, Claudia M.; Koegelenberg, Riaan J.; Odendaal, Christiaan J.; De Beer, T.A.P. (Tjaart Andries Petrus) (BioMed Central, 2009-07)
    BACKGROUND: Up to half a billion human clinical cases of malaria are reported each year, resulting in about 2.7 million deaths, most of which occur in sub-Saharan Africa. Due to the over-and misuse of anti-malarials, ...
  • Discovery-2 : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria 
    Mpangase, Phelelani Thokozani; Szolkiewicz, Michal Jerzy; Le Grange, Misha; Smit, Jeanre H.; Burger, Pieter Buys; Joubert, Fourie (BioMed Central, 2013-03-28)
    BACKGROUND: Drug resistance to anti-malarial compounds remains a serious problem, with resistance to newer pharmaceuticals developing at an alarming rate. The development of new anti-malarials remains a priority, and ...
  • Docking, synthesis, and in vitro evaluation of antimitotic estrone analogs 
    Stander, Andre; Joubert, Fourie; Joubert, Annie M. (Wiley-Blackwell, 2011-03)
    In the present study, Autodock 4.0 was employed to discover potential carbonic anhydrase IX inhibitors that are able to interfere with microtubule dynamics by binding to the Colchicine binding site of tubulin. Modifications ...
  • Draft genome of Cercospora zeina, Fusarium pininemorale, Hawksworthiomyces lignivorus, Huntiella decipiens and Ophiostoma ips 
    Wingfield, Brenda D.; Berger, David Kenneth; Steenkamp, Emma Theodora; Lim, Hye-Jin; Duong, Tuan A.; Bluhm, Burton H.; De Beer, Z. Wilhelm; De Vos, Lieschen; Fourie, Gerda; Naidoo, Kershney; Olivier, Nicholas Abraham; Lin, Yao-Cheng; Van de Peer, Yves; Joubert, Fourie; Crampton, Bridget Genevieve; Swart, Velushka; Soal, Nicole Christine; Tatham, Catherine; Van der Nest, Magrieta Aletta; Van der Merwe, Nicolaas Albertus (Albie); Van Wyk, Stephanie; Wilken, Pieter Markus; Wingfield, Michael J. (International Mycological Association, 2017-11-21)
    The genomes of Cercospora zeina, Fusarium pininemorale, Hawksworthiomyces lignivorus, Huntiella decipiens, and Ophiostoma ips are presented in this genome announcement. Three of these genomes are from plant pathogens and ...
  • The draft genome of Deladenus siricidicola 
    Postma, Alisa; Mlonyeni, X.O.M. (Xolile Osmond Mnyamezeli); Clasen, Frederick Johannes; Joubert, Fourie; Slippers, Bernard (Exeley, 2019)
    The nematode Deladenus siricidicola is used as biological control agent against the invasive woodwasp Sirex noctilio, a serious invasive pest of Pinus plantations globally. The draft genome of this ecologically ...
  • Draft genome sequences of Armillaria fuscipes, Ceratocystiopsis minuta, Ceratocystis adiposa, Endoconidiophora laricicola, E. polonica and Penicillium freii DAOMC 242723 
    Wingfield, Brenda D.; Ambler, Jon M.; Coetzee, Martin Petrus Albertus; De Beer, Z. Wilhelm; Duong, Tuan A.; Joubert, Fourie; Hammerbacher, Almuth; McTaggart, Alistair R.; Naidoo, Kershney; Nguyen, Hai D.T.; Ponomareva, Ekaterina; Santana, Quentin S.; Seifert, Keith A.; Steenkamp, Emma Theodora; Trollip, Conrad; Van der Nest, Magrieta Aletta; Visagie, Cobus M.; Wilken, Pieter Markus; Wingfield, Michael J.; Yilmaz, Neriman (International Mycological Association, 2016-06-21)
    The genomes of Armillaria fuscipes, Ceratocystiopsis minuta, Ceratocystis adiposa, Endoconidiophora laricicola, E. polonica, and Penicillium freii DAOMC 242723 are presented in this genome announcement. These six genomes ...
  • Functional annotation of putative QTL associated with black tea quality and drought tolerance traits 
    Koech, Robert K.; Malebe, Pelly Masixolise; Nyarukowa, Christopher; Mose, Richard; Kamunya, Samson M.; Joubert, Fourie; Apostolides, Zeno (Nature Research, 2019-02)
    The understanding of black tea quality and percent relative water content (%RWC) traits in tea (Camellia sinensis) by a quantitative trait loci (QTL) approach can be useful in elucidation and identification of candidate ...
  • The genome of Eucalyptus grandis 
    Myburg, Alexander Andrew; Grattapaglia, Dario; Tuskan, Gerald A.; Hellsten, Uffe; Hayes, Richard D.; Grimwood, Jane; Jenkins, Jerry; Lindquist, Erika; Tice, Hope; Bauer, Diane; Goodstein, David M.; Dubchak, Inna; Poliakov, Alexandre; Mizrachi, Eshchar; Kullan, Anand Raj Kumar; Hussey, Steven Grant; Pinard, Desre; Van der Merwe, Karen; Singh, Pooja; Van Jaarsveld, Ida; Silva-Junior, Orzenil B.; Togawa, Roberto C.; Pappas, Marilia R.; Faria, Danielle A.; Sansaloni, Carolina P.; Petroli, Cesar D.; Yang, Xiaohan; Ranjan, Priya; Tschaplinski, Timothy J.; Ye, Chu-Yu; Li, Ting; Sterck, Lieven; Vanneste, Kevin; Murat, Florent; Soler, Marcal; Clemente, Helene San; Saidi, Naijib; Cassan-Wang, Hua; Dunand, Christophe; Hefer, Charles Amadeus; Bornberg-Bauer, Erich; Kersting, Anna R.; Vining, Kelly; Amarasinghe, Vindhya; Ranik, Martin; Naithani, Sushma; Elser, Justin; Boyd, Alexander E.; Liston, Aaron; Spatafora, Joseph W.; Dharmwardhana, Palitha; Raja, Rajani; Sullivan, Christopher; Romanel, Elisson; Alves-Ferreira, Marcio; Kulheim, Carsten; Foley, William; Carocha, Victor; Paiva, Jorge; Kudrna, David; Brommonschenkel, Sergio H.; Pasquali, Giancarlo; Byrne, Margaret; Rigault, Philippe; Tibbits, Josquin; Spokevicius, Antanas; Jones, Rebecca C.; Steane, Dorothy A.; Vaillancourt, Rene E.; Potts, Brad M.; Joubert, Fourie; Barry, Kerrie; Pappas Jr, Georgios J.; Strauss, Steven H.; Jaiswal, Pankaj; Grima-Pettenati, Jacqueline; Salse, Jerome; Van de Peer, Yves; Rokhsar, Daniel S.; Schmutz, Jeremy (Nature Publising Group, 2014-06-19)
    Eucalypts are the world’smost widely planted hardwood trees. Their outstanding diversity, adaptability and growth have made them a global renewable resource of fibre and energy. We sequenced and assembled .94% of the ...
  • Genome sequence of Pantoea ananatis LMG20103, the causative agent of Eucalyptus blight and dieback 
    De Maayer, Pieter; Yin Chan, Wai; Venter, S.N. (Stephanus Nicolaas); Toth, Ian K.; Birch, P.R.J. (Paul); Joubert, Fourie; Coutinho, Teresa A. (American Society for Microbiology, 2010-06)
    Pantoea ananatis is a Gram-negative plant pathogen that causes disease on a broad range of host plants, including pineapple, maize, rice, onion, melons, and Eucalyptus, and has been implicated in several cases of human ...
  • Germline sequence variants contributing to cancer susceptibility in South African breast cancer patients of African ancestry 
    Eygelaar, Dewald; Janse van Rensburg, Elizabeth; Joubert, Fourie (Nature Research, 2022-01-17)
    Since the discovery of the breast cancer susceptibility genes, BRCA1 and BRCA2, various other genes conferring an increased risk for breast cancer have been identified. Studies to evaluate sequence variants in cancer ...
  • H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa 
    Mulder, Nicola J.; Adebiyi, Ezekiel; Alami, Raouf; Benkahla, Alia; Brandful, James; Doumbia, Seydou; Everett, Dean; Fadlelmola, Faisal M.; Gaboun, Fatima; Gaseitsiwe, Simani; Ghazal, Hassan; Hazelhurst, Scott; Hide, Winston; Ibrahimi, Azeddine; Fakim, Yasmina Jaufeerally; Jongeneel, C. Victor; Joubert, Fourie; Kassim, Samar; Kayondo, Jonathan; Kumuthini, Judit; Lyantagaye, Sylvester; Makani, Julie; Alzohairy, Ahmed Mansour; Masiga, Daniel; Moussa, Ahmed; Nash, Oyekanmi; Oukem-Boyer, Odile Ouwe Missi; Owusu-Dabo, Ellis; Panji, Sumir; Patterton, Hugh; Radouani, Fouzia; Sadki, Khalid; Seghrouchni, Fouad; Bishop, Ozlem Tastan; Tiffin, Nicki; Ulenga, Nzovu; The H3ABioNet Consortium (Cold Spring Harbor Laboratory Press, 2016-12-01)
    The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping and sequencing technologies and improved data analysis capabilities. ...
  • The identification and characterization of endopolygalacturonases in a South African isolate of Phytophthora cinnamomi 
    Miyambo, Tsakani Magdeline; Backer, Robert; Engelbrecht, Juanita; Joubert, Fourie; Van der Merwe, Nicolaas Albertus (Albie); Van den Berg, Noelani (MDPI, 2022-05-20)
    Phytophthora cinnamomi is an economically important plant pathogen that has caused devastating losses to the avocado industry worldwide. To facilitate penetration and successful colonization of the host plant, pathogens ...
  • In vitro effects of Sutherlandia frutescens extracts in human breast adenocarcinoma and normal breast epithelial cells. 
    Stander, Barend Andre; Joubert, Fourie; Joubert, Annie M.; Theron, D.; Albrecht, C.; Creative Studios, Dept. of Education Innovation (2008-10-21)
    Sutherlandia frutescens is a South African herbal remedy traditionally used for stomach problems, diabetes and lately to improve the overall health in cancer and HIV/AIDS patients. The in vitro influence of crude S. ...