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Browsing by UP Author "Joubert, Annie M."
Now showing items 1-20 of 94
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17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (Wiley, 2014)Microtubules are important targets when studying potential anticancer agents since disturbance of these microtubule dynamics results in cell cycle arrest and cell death. 2-Methoxyestradiol is a naturally occurring metabolite ...
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Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (BioMed Central, 2015-04-22)INTRODUCTION : Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Springer, 2011-11)In anticancer research where the focus is on finding agents that induces cell death while leaving nontumorigenic cells less affected, a novel 2-methoxyestradiol derivative has come forth. 2-Methoxyestradiol-bis-sulfam ...
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Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Biomedical Research Press, 2013)2-Methoxyestradiol-bis-sulphamate (2-MeOE2bisMATE) is a bis-sulphamoylated analogue of a biological estradiol metabolite, 2-methoxyestradiol (2ME2) with potential as an anticancer drug. The aim of this in vitro study was ...
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Visagie, M.H. (Michelle Helen); Joubert, Annie M. (BioMed Central, 2012-08-20)BACKGROUND: Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic ...
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Marais, Sumari; Stander, Barend Andre; Joubert, Annie M. (AOSIS Open Journals, 2013)2-MEBM induced apoptosis and autophagy in HeLa cells and also disrupted the cellular microtubule network. This contributes to the understanding of the in vitro mechanism of action of 2MEBM as a potential anticancer drug.
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Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Future in vitro studies into the mechanism of this potentially anticancer drug are warranted.
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Niemand, Jandeli; Burger, Pieter Buys; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham Izak; Kirk, Kiaran; Phanstiel IV, Otto; Birkholtz, Lyn-Marie (American Society for Microbiology, 2013-06)Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the ...
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Janse van Vuuren, Rustelle; Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Joubert, Annie M. (SpringerOpen, 2015-12)Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that ...
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Skermana, Nicola B.; Joubert, Annie M.; Cronje, Marianne J. (Elsevier, 2011-10)AIM OF STUDY: Oesophageal cancer is the ninth most common cancer in the world and the second most common cancer among South African men. It also has one of the lowest possibilities of cure, with the 5-year survival rate ...
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Verwey, M.; Nolte, Elsie Magdalena; Joubert, Annie M.; Theron, Anne Elisabeth (BioMed Central, 2016-12-08)BACKGROUND : Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in ...
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Joubert, Annie M.; Maritz, Christine; Joubert, Fourie (Biomedical Research Press, 2005-06)2-Methoxyestradiol (2ME), an endogenous metabolite of 17Beta-estradiol, has been reported to play an active role in the induction of apoptosis in both proliferating endothelial and cancer cells. Since it has been indicated ...
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Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M. (Public Library of Science, 2017-04-14)Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R, 13S,14S,17S)-2-ethyl-13-methyl- ...
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Joubert, Annie M.; Van Zyl, Hermia; Laurens, Johannes B.; Lottering, Mona-Liza (Centro Regional de Investigaciones Cientificas Y Tecnologicas / Universidad Nacional de Cuyo, 2009)C2- and C4-position 17β-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased ...
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Sippel, Katherine H.; Stander, Andre; Tu, Chingkuang; Venkatakrishnan, Balasubramanian; Robbins, Arthur H.; Agbandje-McKenna, Mavis; Joubert, Fourie; Joubert, Annie M.; McKenna, Robert (Bentham Science, 2011-10)Sulfamated 2-ethylestra compounds have demonstrated strong anticancer activity, high bioavailability and an ability to bypass liver metabolism by reversibly binding carbonic anhydrase (CA) II in erythrocytes. Another CA ...
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Mercier, Anne Elisabeth; Prudent, Renaud; Pepper, Michael Sean; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechere, Laurence; Joubert, Annie M. (MDPI, 2021-01-29)The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15- tetraene-3-ol-17one (ESE-15-one) ...
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Verwey, M.; Joubert, Annie M.; Visagie, M.H. (Michelle Helen); Annie M.; Theron, A.E. (Biomedical Research Press, 2016)Breast cancer is the most prevalent cancer in women worldwide, contributing to 14% of all new cancer cases and 6.8% of all cancer deaths in 2014. A new area of cancer research has arisen from the discovery of cancer ...
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Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Engelbrecht, Anna-Mart; Joubert, Annie M. (Hindawi Publishing, 2019-12-11)Current chemotherapeutic agents have many side effects and are toxic to normal cells, providing impetus to identify agents that can effectively eliminate tumorigenic cells without damaging healthy cells. The aim of this ...
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Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Albrecht, C.; Joubert, Annie M. (Elsevier, 2014-01)Sutherlandia frutescens (SF) is a traditional Africanmedicinal aid employed for the treatment of various ailments such as inflammation, pulmonary asthma and congestion. The present study was conducted to demonstrate ...
Now showing items 1-20 of 94