Bowyer, Sheila Mary; Sim, John G.M.; Webber, Lynne M.(Health and Medical Publishing Group, 2011-05)
The hepatitis B virus (HBV) is a blood-borne
pathogen approximately 75 - 200 times more
infectious than the human immunodeficiency
virus (HIV), and hyper-endemic in most
parts of sub-Saharan Africa.
Approximately 1 million South Africans are infected with Hepatitis C virus (HCV). The standard of care
(SOC) in South Africa is combination therapy (pegylated interferon and ribavirin). HCV genotypes and/or
mutations in ...
The HCV stem-loop subdomains III-a, -b and -c have been shown to reflect the characteristics of the virus and identify isolates by genus, genotype and subtype. The aim of this study was to investigate the genotype-specific ...
BACKGROUND: Host genetics influence the outcome of HCV disease. HCV is also highly mutable and escapes host immunity. HCV genotypes are geographically distributed and HCV subtypes have been shown to have distinct repertoires ...
Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Mphahlele, M. Jeffrey; Blackard, Jason T.; Bowyer, Sheila Mary(Wiley, 2013-11)
Hepatitis B virus (HBV) is a serious global health problem, and HBV genotype is an important determinant of disease progression and treatment outcome. The aim of this study was to assess variations of the precore/core ...
