Abstract:
Drug resistance to single therapeutic treatment in HIV infected individuals has promoted
research into combined treatments. In this paper we propose a stochastic model under
combined therapeutic treatment by extending the model of HIV pathogenesis under treatment
by anti-viral drugs given in [Perelson AS, Neumann AU, Markowits M, Leonard JM
& Ho DD, 1996, HIV-1 dynamics in vivo virion clearance rate, infected cell life span, and
viral generation time, Science New Series, 271, pp. 1582-1586]. Variance and co-variance
structures of variables are obtainable via this approach in addition to the mean numbers of
free HIV, infectious free HIV and non-infectious free HIV that were obtained by Perelson
et al. Comparing simulated data for before and after treatment indicates the importance of
combined treatment and its overall e ect(s).
