||Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold,
however the nature of the mechanisms that determine this variability is unresolved. Here, we assess
the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid
compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian
clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the
three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body
temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them
display signatures of greater stabilizing selection in long-living species, and cluster in functional groups
related to signaling and protein-modification processes. These findings point towards the existence of
defined molecular mechanisms underlying variation in maximal lifespan among mammals.
||The National Natural Science Foundation of China (grant 31420103920), Strategic
Priority Research Program of the Chinese Academy of Sciences (grant XDB13010200), the National Natural Science Foundation of China (grant 91331203), the National One Thousand Foreign Experts Plan (grant
WQ20123100078), the Bureau of International Cooperation, Chinese Academy of Sciences (grant GJHZ201313)
and the Federal Targeted Program for Research and Development in Priority Areas of Advancement of the
Russian Scientific and Technological Complex for 2014–2020 (the Ministry of Education and Science of the
Russian Federation), grant № 14.615.21.0002, the Unique identifier of the agreement: RFMEFI61515×0002.
Additional support was obtained from the European Research Council (advanced grant 294678 to GRL).
||Bozek, k, Khrameeva, EE, Reznick, J, Omerbasic, D, Bennett, NC, Lewin, GR, Azpurua, J, Gorbunova, V, Seluanov, A, Regnard, P, Wanert, F, Marchal, J, Pifferi, F, Aujard, F, Liu, Z, Shi, P, Paabo, S, Schroeder, F, Willmitzer, L, Giavalisco, P & Khaitovich, P 2017, 'Lipidome determinants of maximal lifespan in mammals', Scientific Reports, vol. 7, no. 5, pp. 1-10.