The influences of the nature of the diet and of starvation on the concentration curve of sulphanilamide in the blood of sheep after oral dosing

Abstract

It has been shown that the concentration curve of sulphanilamide in the blood of sheep after oral dosing is profoundly influenced by the basic diet and by starvation. In view of this and other similar findings, it is emphasised that, especially in the ruminant, no pharmacological or toxicological findings can be correctly interpreted without due regard being given to the basic diet and the feeding regime.