Abstract:
Indeterminate HIV PCR results represent missed diagnostic opportunities within South
Africa’s early infant diagnosis programme. These results not only delay diagnosis and
appropriate management but are also a source of confusion and apprehension amongst
clinicians and caregivers. We describe the extent of indeterminate HIV PCR results within
South Africa’s early infant diagnosis programme and provide recommendations for the
management of these cases, both in terms of laboratory practice and the clinical care of the
infants.