dc.contributor.author |
Dell, Leigh-Anne
|
|
dc.contributor.author |
Spocter, Muhammad A.
|
|
dc.contributor.author |
Patzke, Nina
|
|
dc.contributor.author |
Karlson, Karl Æ.
|
|
dc.contributor.author |
Alagaili, Abdulaziz N.
|
|
dc.contributor.author |
Bennett, Nigel Charles
|
|
dc.contributor.author |
Muhammed, Osama B.
|
|
dc.contributor.author |
Bertelsen, Mads F.
|
|
dc.contributor.author |
Siegel, Jerome M.
|
|
dc.contributor.author |
Manger, Paul R.
|
|
dc.date.accessioned |
2016-08-01T07:21:05Z |
|
dc.date.issued |
2015-10 |
|
dc.description.abstract |
The species of the cetacean and artiodactyl suborders, which make up the
cetartiodactyl order, have very different arousal thresholds and sleep-wake systems.
The aim of this study was to determine whether cetaceans or artiodactyls have
differently organized orexinergic arousal systems by examining the density of
orexinergic innervation to the cerebral cortex. This study provides a comparison of
orexinergic bouton density in the cerebral cortex of twelve cetartiodactyl species by
means of immunohistochemical staining and stereological analysis. It was observed
that the morphology of the axonal projections of the orexinergic system to the cerebral
cortex was similar across all species, as the presence, size and proportion of large and
small orexinergic boutons were similar. Despite this, orexinergic bouton density was
lower in the cerebral cortex of cetaceans compared to artiodactyls, even when
corrected for brain mass, neuron density, glial density and glial: neuron ratio. Glial
density was identified as the major determinant for the observed differences. It appears
a synergy exists between the orexinergic neurons and their projections, glial cells, and
the biochemical correlates of appetitive drive and arousal, but further studies need to
be performed to understand the full extent of the orexinergic system and its role in
sustained arousal. |
en_ZA |
dc.description.department |
Mammal Research Institute |
en_ZA |
dc.description.department |
Zoology and Entomology |
en_ZA |
dc.description.embargo |
2016-10-31 |
|
dc.description.librarian |
hb2016 |
en_ZA |
dc.description.sponsorship |
This work was mainly supported by funding from the South
African National Research Foundation (P.R.M., N.C.B.) and by a fellowship within the
Postdoctoral-Program of the German Academic Exchange Service, DAAD (N.P.). The
work was also supported by an IOER R&G Grant from Des Moines University (#12-
13-03) (M.A.S.), Reykjavik University 2010 Development Fund (K.Æ.K.), the
Deanship of Scientific Research at the King Saud University through the research
group project number RGP_020 (A.N.A., O.B.M.), and NIH grant DA
2R01MH064109 and the Department of Veterans Affairs (J.M.S). |
en_ZA |
dc.description.uri |
http://www.elsevier.com/locate/jchemneu |
en_ZA |
dc.identifier.citation |
Dell, L-A, Spocter, MA, Patzke, N, Karlson, KÆ, Alagaili, AN, Bennett, NC, Muhammed, OB, Bertelsen, MF, Siegler, JM & Manger, PR 2015, 'Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls', Journal of Chemical Neuroanatomy, vol. 68, pp. 61-76. |
en_ZA |
dc.identifier.issn |
0891-0618 (print) |
|
dc.identifier.issn |
1873-6300 (online) |
|
dc.identifier.other |
10.1016/j.jchemneu.2015.07.007 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/56146 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2015 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, vol. 68, pp. 61-76, 2015. doi : 10.1016/j.jchemneu.2015.07.007. |
en_ZA |
dc.subject |
Cetartiodactyla |
en_ZA |
dc.subject |
Orexin |
en_ZA |
dc.subject |
Hypocretin |
en_ZA |
dc.subject |
Comparative neuroanatomy |
en_ZA |
dc.subject |
Evolution |
en_ZA |
dc.subject |
Comparative sleep |
en_ZA |
dc.subject |
Mammalia |
en_ZA |
dc.title |
Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls |
en_ZA |
dc.type |
Postprint Article |
en_ZA |