Aetiology of jaagsiekte : transmission by means of subcellular fractions and evidence for the involvement of a retrovirus
Verwoerd, Daniel Wynand; De Villiers, Ethel-Michele; Williamson, Anna-Lise; Steyn, P.J.J.; Bigalke, R.D.; Cameron, Colin McKenzie; Gilchrist, Frances M.C.; Morren, A.J.; Verster, Anna J.M.; Verwoerd, Daniel Wynand; Walker, Jane B.
Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by subinoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the Y-chromosome in the tumour cells. A second
mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenates.
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