dc.contributor.author |
Adewusi, Emmanuel Adekanmi
|
|
dc.contributor.author |
Fouche, Gerda
|
|
dc.contributor.author |
Steenkamp, Vanessa
|
|
dc.date.accessioned |
2016-05-26T09:10:23Z |
|
dc.date.available |
2016-05-26T09:10:23Z |
|
dc.date.issued |
2013 |
|
dc.description.abstract |
Amyloid-beta peptide (Aβ) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative
disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on Aβ-
induced cell death. Cytotoxicity of the ethanol extracts of the plants was determined against SH-SY5Y (human neuroblastoma)
cells which were untreated, as well as toxically induced with Aβ, using the MTT and neutral red uptake assays. Cell viability was
reduced to 16% when exposed to 20 μM Aβ25-35 for 72 h. The methanol extract of the roots of Ziziphus mucronata Willd., Lannea
schweinfurthii (Engl.) Engl. and Terminalia sericea Burch. ex DC., were the least toxic to the SH-SY5Ycells at the highest
concentration tested (100 μg/ml). All four plants tested were observed to reduce the effects of Aβ-induced neuronal cell death,
indicating that they may contain compounds which may be relevant in the prevention of AD progression. |
en_ZA |
dc.description.department |
Pharmacology |
en_ZA |
dc.description.librarian |
am2016 |
en_ZA |
dc.description.sponsorship |
The National Research Foundation (Pretoria) and RESCOM
(University of Pretoria). |
en_ZA |
dc.description.uri |
http://journals.sfu.ca/africanem/index.php/ajtcam |
en_ZA |
dc.identifier.citation |
Adewusia, EA, Fouche, G & Vanessa Steenkamp, V 2013, 'Effect of four medicinal plants on amyloid-p induced neurotoxicity in SH-SY5Y cells', African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM), vol. 10, no. 4, pp. 6-11. |
en_ZA |
dc.identifier.issn |
0189-6016 |
|
dc.identifier.other |
10.4314/ajtcam.v10i4.2 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/52755 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
African Networks on Ethnomedicines |
en_ZA |
dc.rights |
This work is licensed under the Creative Commons Attribution 3.0 Unported License. |
en_ZA |
dc.subject |
Medicinal plants |
en_ZA |
dc.subject |
Neurodegenerative disorders |
en_ZA |
dc.subject |
Neurotoxicity |
en_ZA |
dc.subject |
Amyloid-beta peptide (Aβ) |
en_ZA |
dc.subject |
Alzheimer’s disease (AD) |
en_ZA |
dc.subject |
SH-SY5Y cells |
en_ZA |
dc.title |
Effect of four medicinal plants on amyloid-p induced neurotoxicity in SH-SY5Y cells |
en_ZA |
dc.type |
Article |
en_ZA |