dc.contributor.author |
Tshabalala, Mqondisi
|
|
dc.contributor.author |
Mellet, Juanita
|
|
dc.contributor.author |
Pepper, Michael Sean
|
|
dc.date.accessioned |
2016-04-18T09:07:48Z |
|
dc.date.available |
2016-04-18T09:07:48Z |
|
dc.date.issued |
2015 |
|
dc.description.abstract |
Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations,
there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defensemechanism
mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa,
HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation
therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and
defines a need for information of this kind.This information will support disease association studies, provide guidance in vaccine
design, and improve transplantation outcomes. |
en_ZA |
dc.description.department |
Immunology |
en_ZA |
dc.description.librarian |
am2016 |
en_ZA |
dc.description.sponsorship |
The Medical Research Council of South
Africa in terms of MRC’s Flagships Awards Project SAMRCRFA-UFSP-01-2013/STEM CELLS, the Institute for Cellular and Molecular Medicine of the University of Pretoria, and the National Research Foundation of South Africa. |
en_ZA |
dc.description.uri |
http://www.hindawi.com/journals/jir |
en_ZA |
dc.identifier.citation |
Tshabalala, M, Mellet, J & Pepper, MS 2015, 'Human leukocyte antigen diversity : a Southern African perspective', Journal of Immunology Research, vol. 2015, art. no. 746151, pp. 1-11. |
en_ZA |
dc.identifier.issn |
2314-8861 (print) |
|
dc.identifier.issn |
2314-7156 (online) |
|
dc.identifier.other |
10.1155/2015/746151 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/52043 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Hindawi Publishing |
en_ZA |
dc.rights |
© 2015 Mqondisi Tshabalala et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited. |
en_ZA |
dc.subject |
African populations |
en_ZA |
dc.subject |
Immune system |
en_ZA |
dc.subject |
Southern Africa |
en_ZA |
dc.subject |
Human leukocyte antigen (HLA) |
en_ZA |
dc.title |
Human leukocyte antigen diversity : a Southern African perspective |
en_ZA |
dc.type |
Article |
en_ZA |