Research Articles (Medical Oncology)

Research Articles (Medical Oncology)

 

Recent Submissions

  • Dreosti, Lydia M.; Jacobus, S.J.; Rajkumar, S.V.; Weiss, M.; Stewart, A.K.; Stadtmauer, E.A.; Callander, N.S.; Lacy, M.Q.; Fonseca, R. (Nature Publishing Group, 2016)
    Long-awaited results from the the Southwest Oncology Group (SWOG) trial comparing bortezomib–lenalidomide-dexamethasone (VRd) versus lenalidomide-dexamethasone (Rd) as induction treatment for previously untreated multiple ...
  • Pretorius, Marthinus W.; Venter, Marietjie; Cohen, Cheryl; Moyes, Jocelyn; Tempia, Stefano; Groome, Michelle; Walaza, Sibongile; Dawood, Halima; Chhagan, Meera; Haffejee, Summaya; Variava, Ebrahim; Kahn, Kathleen; Von Gottberg, Anne; Wolter, Nicole; Cohen, Adam L.; Malope-Kgokong, Babatyi; Madhi, Shabir A. (Public Library of Science, 2015-03-18)
    INTRODUCTION Data on the burden and risk groups for influenza-associated mortality from Africa are limited. We aimed to estimate the incidence and risk-factors for in-hospital influenza-associated severe acute respiratory ...
  • Dreosti, Lydia M.; Hurvitz, Sara A.; Andre, Fabrice; Jiang, Zefei; Shao, Zhimin; Mano, Max S.; Neciosup, Silvia P.; Tseng, Ling-Min; Zhang, Qingyuan; Shen, Kunwei; Liu, Donggeng; Burris, Howard A.; Toi, Masakazu; Buyse, Marc E.; Cabaribere, David; Lindsay, Mary-Ann; Rao, Shantha; Pacaud, Lida Bubuteishvili; Taran, Tetiana; Slamon, Dennis (Elsevier, 2015-07)
    BACKGROUND : mTOR inhibition has been shown to reverse trastuzumab resistance from hyperactivated the PIK/AKT/mTOR pathway due to PTEN loss, by sensitizing PTEN-deficient tumors towards trastuzumab. The BOLERO-1 study ...
  • Dreosti, Lydia M.; De Azambuja, Evandro; Holmes, Andrew P.; Piccart-Gebhart, Martine; Holmes, Eileen; Di Cosimo, Serena; Swaby, Ramona; Untch, Michael; Jackisch, Christian; Lang, Istvan; Smith, Ian; Boyle, Frances; Xu, Binghe; Barrios, Carlos H.; Perez, Edith A.; Azim Jr., Hatem A.; Kim, Sung-Bae; Kuemmel, Sherko; Huang, Chiun-Sheng; Vuylsteke, Peter; Hsieh, Ruey-Kuen; Gorbunova, Vera; Eniu, Alexandru; Tavartkiladze, Natalia; Gelber, Richard D.; Eidtmann, Holger; Baselga, José (Elsevier, 2014-09)
    BACKGROUND : We investigated whether the increase in pathological complete response (pCR) rates with neoadjuvant combination of lapatinib and trastuzumab in addition to weekly paclitaxel would translate into improved survival ...
  • Wessels, P.F.; Jacobson, B.F.; Louw, S.; Buller, H.; Mer, M.; De Jong, P.R.; Rowji, P.; Schapkaitz, E.; Adler, D.; Beeton, A.; Hsu, H-C.; Haas, S. (Health and Medical Publishing Group, 2013-04)
    BACKGROUND: Pharmacological prophylactic anticoagulation in many countries, including South Africa, is under-prescribed. This has resulted in unacceptable rates of morbidity and mortality. METHOD: The Southern African ...
  • Wessels, P.F. (Open Journals Systems, 2012)
    The relationship between cancer and thrombosis has been known for many years. Thrombotic risk is increased in the patient with cancer, and the diagnosis of venous thromboembolism at the time that a malignancy presents ...
  • Wessels, P.F. (Clinics Cardiv, 2012-03)
    Diabetic patients have a high risk of developing arterial disease (coronary artery, cerebrovascular and peripheral arterial disease) and are therefore often given antiplatelet therapy. Although only retrospective studies ...
  • Dreosti, Lydia M.; Pool, Roger; Louw, V.J.; Bassa, F.; Chan, S.W.; Du Toit, M.; Ferreira, M.; Gartrell, K.; Gunther, K.; Jogessar, V.; Littleton, N.; Mahlangu, J.; McDonald, A.; Patel, M.; Ruff, P.; Schmidt, A.; Sissolak, G.; Swart, Andre; Verburgh, E.; Webb, M.J. (Health and Medical Publishing Group, 2011-12)
    INTRODUCTION: Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ...
  • Dreosti, Lydia M.; Louw, V.J.; Ruff, P.; Jogessar, V.; Moodley, D.; Novitzky, N.; Patel, M.; Schmidt, A.; Willem, Pascale (Health and Medical Publishing Group, 2011-11)
    INTRODUCTION: Chronic myeloid leukaemia (CML) is a chronic myeloproliferative disorder characterised by a chromosomal translocation between the long arms of chromosomes 9 and 12 resulting in the formation of the BCR-ABL ...
  • Saglio, Giuseppe; Kim, Dong-Wook; Issaragrisil, Surapol; Le Coutre, Philipp; Etienne, Gabriel; Lobo, Clarisse; Pasquini, Ricardo; Clark, Richard E.; Hochhaus, Andreas; Hughes, Timothy P.; Gallagher, Neil; Hoenekopp, Albert; Dong, Mei; Haque, Ariful; Larson, Richard A. (Massachusetts Medical Society, 2010-06)
    BACKGROUND: Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety of nilotinib, as compared with imatinib, in patients with newly diagnosed Philadelphia ...