dc.contributor.author |
Outhoff, Kim
|
|
dc.date.accessioned |
2015-08-20T07:17:37Z |
|
dc.date.available |
2015-08-20T07:17:37Z |
|
dc.date.issued |
2015 |
|
dc.description.abstract |
Switching antidepressants because of lack of efficacy or unacceptable side-effects, while often required in general practice,
may result in toxic drug-drug interactions, worsening depression or unpleasant discontinuation reactions. Switching strategies
to minimise these risks include immediate switching, cross-tapering or incorporating a washout period. Immediate switching is
generally possible when substituting a selective serotonin reuptake inhibitor or a serotonin and noradrenaline reuptake inhibitor
for a drug from its own class. Cross-tapering over a period of weeks is preferred when switching between different antidepressant
classes or from high-dose antidepressants. Dangerous interactions necessitate the observance of an adequate washout period
when switching to and from monoamine oxidase inhibitors. |
en_ZA |
dc.description.librarian |
am2015 |
en_ZA |
dc.description.uri |
http://www.tandfonline.com/ojfp |
en_ZA |
dc.identifier.citation |
Outhoff, K 2015, 'Switching antidepressants', South African Family Practice, vol. 57, no. 2, pp.32-34. |
en_ZA |
dc.identifier.issn |
2078-6190 (print) |
|
dc.identifier.issn |
2078-6204 (online) |
|
dc.identifier.uri |
http://hdl.handle.net/2263/49405 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
MedPharm Publications |
en_ZA |
dc.rights |
© 2015 The Author(s) |
en_ZA |
dc.subject |
Switching antidepressants |
en_ZA |
dc.subject |
Discontinuation reactions |
en_ZA |
dc.subject |
Immediate switching |
en_ZA |
dc.subject |
Cross-tapering |
en_ZA |
dc.subject |
Washout period |
en_ZA |
dc.title |
Switching antidepressants |
en_ZA |
dc.type |
Article |
en_ZA |