• Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 

  Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)

  Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
• Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 

  Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)

  Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...
• Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 

  Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen Bates; Dlamini, Zodwa (MDPI, 2023-08-07)

  Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
• Multi-omics and management of follicular carcinoma of the thyroid 

  Luvhengo, Thifhelimbilu Emmanuel; Bombil, Ifongo; Mokhtari, Arian; Moeng, Maeyane Stephens; Demetriou, Demetra Danielle; Sanders, Claire; Dlamini, Zodwa (MDPI, 2023-04-19)

  Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid gland, accounting for up to 20% of all primary malignant tumors in iodine-replete areas. The diagnostic work-up, staging, risk stratification, ...
• Towards perioperative point-of-care viscoelastic testing 

  Wessels, Pieter Frederik (Medpharm Publications, 2023)

  No abstract available.
• The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule : targeting cancer cells signaling PI3K and AKT kinase pathway 

  Gupta, Kartikey Kumar; Sharma, Kamal Kant; Chandra, Harish; Panwar, Himalaya; Bhardwaj, Nitin; Altwaijry, Najla A.; Alsfouk, Aisha A.; Dlamini, Zodwa; Afzal, Obaid; Altamimi, Abdulmalik S.A.; Khan, Shahanavaj; Mishra, Abhay Prakash (Frontiers Media S.A., 2022-12)

  BACKGROUND : Breast cancer is the most common type of cancer in women, and vast research is being conducted throughout the world for the treatment of this malignancy by natural products using various computational approaches. ...
• Viral encoded miRNAs in tumorigenesis : theranostic opportunities in precision oncology 

  Hull, Rodney; Marima, Rahaba; Alaouna, Mohammed; Demetriou, Demetra Danielle; Reis, Rui Manuel; Molefi, Thulo; Dlamini, Zodwa (MDPI, 2022-07-18)

  About 15% of all human cancers have a viral etiology. Although progress has been made, understanding the viral oncogenesis and associated molecular mechanisms remain complex. The discovery of cellular miRNAs has led to ...
• Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer : HPV oncogenesis, clinical significance and therapeutic opportunities 

  Basera, Afra; Hull, Rodney; Demetriou, Demetra Danielle; Bates, David O.; Kaufmann, Andreas Martin; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2022-09-16)

  Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer. However, numerous ...
• Towards the development of a new technique for mastectomy‐scar electron beam treatment using a variable collimator and computer‐automated treatment table control 

  Mlambo, Musikavanhu Roy (University of Pretoria, 2023)

  Breast cancer in women is the most prevalent cancer in both developed and less developed countries, with an incidence of about 2.3 million new cases diagnosed in 2020, which is about 25% of all cancers in women. Several ...
• Influence of the microbiome metagenomics and epigenomics on gastric cancer 

  Mathebela, Precious; Damane, Botle Precious; Mulaudzi, Thanyani Victor; Mkhize-Khwitshana, Zilungile Lynette; Gaudji, Guy Roger; Dlamini, Zodwa (MDPI, 2022-11)

  Gastric cancer (GC) is one of the major causes of cancer deaths worldwide. The disease is seldomly detected early and this limits treatment options. Because of its heterogeneous and complex nature, the disease remains ...
• Molecular profiling of long non-coding RNAs in prostate cancer cell lines 

  Mbeje, Mandisa Pearl (University of Pretoria, 2023)

  Prostate cancer (PCa) incidence rates continue to rise with an estimation of 375 000 deaths and 1.4 million new cases in the year 2020. It has become the second most commonly occurring cancer and the fifth most frequent ...
• Prostate cancer disparities and management in southern Africa : insights into practices, norms and values 

  Marima, Rahaba; Mbeje, Mandisa; Hull, Rodney; Demetriou, Demetra Danielle; Mtshali, Nompumelelo; Dlamini, Zodwa (Dove Press, 2022-12)

  Prostate cancer (PCa) is a leading cause of mortality in men of African origin. While men of African descent in high-income countries (HICs) demonstrate poor prognosis compared to their European counterparts, African men ...
• Exploiting the molecular basis of oesophageal cancer for targeted therapies and biomarkers for drug response : guiding clinical decision-making 

  Mbatha, Sikhumbuzo Z.; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-09-22)

  Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality ...
• Microbiomes, epigenomics, immune response, and splicing signatures interplay : potential use of combination of regulatory pathways as targets for malignant mesothelioma 

  Setlai, Botle Precious; Mkhize-Kwitshana, Zilungile Lynette; Mehrotra, Ravi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa (MDPI, 2022-08-12)

  Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries. According to literature, the incidence of MM ...
• Editorial : Cholesterol and cancer drug resistance : molecular, signaling, and therapeutic aspects 

  Kaur, Mandeep; Dlamini, Zodwa (Frontiers Media S.A., 2022-09-15)

  No abstract available.
• Microbiomics in collusion with the nervous system in carcinogenesis : diagnosis, pathogenesis and treatment 

  Hull, Rodney; Lolas, Georgios; Makrogkikas, Stylianos; Jensen, Lasse D.; Syrigos, Konstantinos N.; Evangelou, George; Padayachy, Llewellyn; Egbor, Cyril; Mehrotra, Ravi; Makhafola, Tshepiso Jan; Oyomno, Meryl; Dlamini, Zodwa (MDPI, 2021-10-11)

  The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut ...
• Genomics and molecular analysis of RPL9 and LIAS in lung cancer : emerging implications in carcinogenesis 

  Dlamini, Zodwa; Marima, Rahaba; Hull, Rodney; Syrigos, Konstantinos N.; Lolas, Georgios; Mphahlele, Lebogang; Mbita, Zukile (Elsevier, 2021-08-11)

  Worldwide, lung cancer is a leading cause of cancer-related deaths and is the most commonly diagnosed form of cancer. A major characteristic of lung cancer is its profound clinical, histological and molecular heterogeneity. This ...
• Genetic drivers of head and neck squamous cell carcinoma : aberrant splicing events, mutational burden, hpv infection and future targets 

  Dlamini, Zodwa; Alaouna, Mohammed; Mbatha, Sikhumbuzo Z.; Bhayat, Ahmed; Mabongo, Mzubanzi; Chatziioannou, Aristotelis; Hull, Rodney (MDPI, 2021-03-15)

  Head and neck cancers include cancers that originate from a variety of locations. These include the mouth, nasal cavity, throat, sinuses, and salivary glands. These cancers are the sixth most diagnosed cancers worldwide. ...
• Immunosuppressive signaling pathways as targeted cancer therapies 

  Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)

  Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
• MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets 

  Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen Bates; Dlamini, Zodwa (MDPI, 2021-12-02)

  Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...

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