Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)
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| dc.contributor.author | Cockeran, Riana
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| dc.contributor.author | Herbert, Jenny A.
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| dc.contributor.author | Mitchell, Timothy J.
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| dc.contributor.author | Dix-Peek, Thérèse
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| dc.contributor.author | Dickens, Caroline
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| dc.contributor.author | Anderson, Ronald
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| dc.contributor.author | Feldman, Charles
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| dc.date.accessioned | 2014-09-18T10:21:33Z | |
| dc.date.available | 2014-09-18T10:21:33Z | |
| dc.date.issued | 2014-07 | |
| dc.description.abstract | Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0 . 0 1 4 –0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen. | en_US |
| dc.description.librarian | hb2014 | en_US |
| dc.description.sponsorship | South African Medical Research Council and the National Research Foundation of South Africa | en_US |
| dc.description.uri | http://www.hindawi.com/journals/bmri/ | en_US |
| dc.identifier.citation | Cockeran, R, Herbert, JA, Mitchell, TJ, Dix-Peek, T, Dickens, C, Anderson, R & Feldman, C 2014, 'Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)', BioMed Research International, vol. 2014, art. #976347, pp. 1-4. | en_US |
| dc.identifier.issn | 2314-6133 (print) | |
| dc.identifier.issn | 2314-6141 (online) | |
| dc.identifier.other | 10.1155/2014/976347 | |
| dc.identifier.uri | http://hdl.handle.net/2263/42034 | |
| dc.language.iso | en | en_US |
| dc.publisher | Hindawi Publishing Corporation | en_US |
| dc.rights | © 2014 Riana Cockeran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
| dc.subject | Exposure of a 23F serotype strain | en_US |
| dc.subject | Streptococcus pneumoniae | en_US |
| dc.subject | Cigarette smoke condensate | en_US |
| dc.title | Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11) | en_US |
| dc.type | Article | en_US |
