Tick cell lines : tools for tick and tick-borne disease research

Bell-Sakyi, Lesley; Zweygarth, Erich; Blouin, Edmour F.; Gould, Ernest A.; Jongejan, Frans

UPSpace Home
→
Veterinary Science
→
Veterinary Tropical Diseases
→
Research Articles (Veterinary Tropical Diseases)
→
View Item

dc.contributor.author	Bell-Sakyi, Lesley
dc.contributor.author	Zweygarth, Erich
dc.contributor.author	Blouin, Edmour F.
dc.contributor.author	Gould, Ernest A.
dc.contributor.author	Jongejan, Frans
dc.date.accessioned	2007-09-26T06:02:02Z
dc.date.available	2007-09-26T06:02:02Z
dc.date.issued	2007-09
dc.description.abstract	Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host–vector–pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine.	en
dc.description.sponsorship	Writing of this article has been facilitated through The Integrated Consortium on Ticks and Tick-borne Diseases (ICTTD-3) financed by the International Cooperation Programme of the European Union through Coordination Action Project no. 510561. Current research on tick cell lines (L.B-S.) is supported by the Wellcome Trust project 0757990 ‘Adapting recombinant anti-tick vaccines to livestock in Africa’ and the European Union project INCO-CT-2005–003713 ’EPIGENEVAC’. Research on Anaplasma sp. (Omatjenne) in tick cells (E.Z.) has been supported by the USAID Cooperative Development Research Program, Grant Agreement No. TA-MOU-01-C21–027. Research on A. marginale in tick cells (E.F.B.) has been supported by the USDA–NRI Program. E.A.G. is supported by the European Union 6th Framework programme ‘VIZIER’.	en
dc.format.extent	426513 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Bell-Sakyi, L, Zweygarth, E, Blouin, EF, Gould, EA & Jongejan, F 2007, ‘Tick-host-pathogen interactions in the post-genomic era’, Trends in Parasitology, vol. 23, no. 9, pp. 450-457 [http://www.sciencedirect.com/science/journal/14714922]	en
dc.identifier.issn	1471-4922
dc.identifier.other	10.1016/j.pt.2007.07.009
dc.identifier.uri	http://hdl.handle.net/2263/3557
dc.language.iso	en	en
dc.publisher	Elsevier	en
dc.rights	Elsevier	en
dc.subject	Tick-borne diseases	en
dc.subject	Ticks	en
dc.subject.lcsh	Tick-borne diseases -- Research	en
dc.subject.lcsh	Ticks as carriers of disease	en
dc.subject.lcsh	Ticks -- Research	en
dc.subject.lcsh	Host-parasite relationships	en
dc.title	Tick cell lines : tools for tick and tick-borne disease research	en
dc.type	Postprint Article	en