dc.contributor.author |
Coetzee, Peter
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dc.contributor.author |
Nel, Louis Hendrik
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dc.date.accessioned |
2007-08-29T11:02:11Z |
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dc.date.available |
2007-08-29T11:02:11Z |
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dc.date.issued |
2007-06 |
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dc.description.abstract |
Towards understanding the molecular epidemiology of a severe dog rabies epidemic in the KwaZulu Natal province of South Africa, we analyzed a variable 592 nucleotide genome sequence domain of 170 rabies viruses from KwaZulu Natal and surrounding regions. Viruses from the KwaZulu Natal and Eastern Cape provinces belonged to a unique lineage, circulating as two independent and expanding epidemiological cycles. The first presented as closely related dog cycles along the eastern coastal regions of the two provinces, while the second, in northern KwaZulu Natal, has entered into at least one wildlife reservoir, the black backed jackal. We underline the success and opportunism of rabies in southern Africa, in a likely reflection of the emergence and radiation of rabies in new host species and locales throughout the larger continent as a whole. |
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dc.description.sponsorship |
The authors would like to express their gratitude towards Dr. J. Randles and the staff from the Veterinary Institute at Allerton in KwaZulu Natal for access to their collection of rabies positive samples, and for preparing these samples for transport. We would also like to thank Ms. W. Markotter, as well as Dr. C.T. Sabeta and staff from the rabies unit at the Onderstepoort Veterinary Institute (OVI) for support in sample handling and preparation. We further thank Ms. J. Kehrhahn (UP) for the preparation of the Eastern Cape virus samples. This work was funded in part by a grant from the South African National Research Foundation (Gun 2054280/Pun 263880). |
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dc.format.extent |
756417 bytes |
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dc.format.mimetype |
application/pdf |
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dc.identifier.citation |
Coetzee, P & Nel, LH 2007. ‘Emerging epidemic dog rabies in coastal South Africa: A molecular epidemiological analysis’, Virus Research, vol. 126,issues 1-2, pp. 186-195 [http://www.sciencedirect.com/science/journal/01681702] |
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dc.identifier.issn |
01681702 |
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dc.identifier.other |
10.1016/j.virusres.2007.02.020 |
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dc.identifier.uri |
http://hdl.handle.net/2263/3372 |
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dc.language.iso |
en |
en |
dc.publisher |
Elsevier |
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dc.rights |
Elsevier |
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dc.subject |
G-L intergenic region |
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dc.subject |
Pseudogene |
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dc.subject.lcsh |
Rabies -- Epidemiology |
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dc.subject.lcsh |
Rabies in animals -- KwaZulu-Natal (South Africa) |
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dc.subject.lcsh |
Molecular epidemiology |
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dc.subject.lcsh |
Rabies in animals -- Eastern Cape (South Africa) |
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dc.subject.lcsh |
Dogs -- Diseases |
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dc.subject.lcsh |
Yellow mongoose (Cynictis penicillata) |
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dc.subject.lcsh |
Black-backed jackal |
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dc.subject.lcsh |
Nucleotide sequence |
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dc.subject.lcsh |
Dogs -- Viruses |
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dc.title |
Emerging epidemic dog rabies in coastal South Africa : a molecular epidemiological analysis |
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dc.type |
Postprint Article |
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