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Theses and Dissertations (Immunology): Recent submissions
Now showing items 1-20 of 48
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(University of Pretoria, 2023)Obesity is a pandemic affecting both adults and children with an increasing annual prevalence. Adipogenesis, a process in which adipocyte precursors differentiate into mature adipocytes, is considered an important process ...
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(University of Pretoria, 2023)The present study was undertaken with the initial objective of investigating the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the ...
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(University of Pretoria, 2023)Breast cancer (BC) is the most prevalent cancer in females and the leading cause of cancer deaths. Treatment options include mastectomy, chemotherapy, and radiotherapy. While these treatments can improve 5-year survival ...
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(University of Pretoria, 2022)The aim of this project was to develop assays that will allow for high-throughput screening to monitor adipogenesis. Such an assay may be useful for the identification of potential drug targets during the process of ...
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(University of Pretoria, 2014)No abstract
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(University of Pretoria, 2010)The major cause of HIV-related mortality in Sub-Saharan countries is pulmonary tuberculosis (TB), which is an escalating threat due to the emergence of multidrug resistant (MDR) and extremely multidrug resistant (XDR) TB. ...
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(University of Pretoria, 2020)Background: The chemotherapy of tuberculosis (TB) patients is administered for a six to nine- month period consisting of an intensive phase during the first two months with four primary anti- TB drugs, rifampicin (RMP), ...
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(University of Pretoria, 2019)Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium that frequently colonises the nasopharynx of healthy humans. In susceptible hosts, especially children under 5 years with underdeveloped immune systems ...
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(University of Pretoria, 2019)The human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS), a condition characterized by depletion of CD4+ T cells and other immune system dysfunctions. Due to its widespread ...
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(University of Pretoria, 2019)Obesity is characterized by an excessive amount of body fat which can negatively affect health as it is a risk factor for various non-communicable diseases such as cardiovascular disease and diabetes, amongst others. A ...
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(University of Pretoria, 2019)The dissertation describes the production and titration of molecular clones of HIV-1B and HIV-1C primary isolates, as well as the assessment of haematopoietic stem and progenitor cell function by colony-forming unit assay ...
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(University of Pretoria, 2018)There is documented evidence of high genetic diversity amongst African populations, but there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA genes are highly polymorphic, and encode ...
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(University of Pretoria, 2018)The study addressed the development and evaluation of novel procedures for the rapid, reproducible and efficient measurement of T cell alloreactivity both pre- and post-transplantation, with the aim of optimizing donor/ ...
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(University of Pretoria, 2017)Patients with sepsis need to be distinguished from those with systemic inflammation due to non-infectious causes (SIRS) so that empiric antimicrobial therapy can be administered timeously to those with sepsis. The current ...
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(University of Pretoria, 2017)Gene therapy is a field in medical research that is being investigated for the treatment of genetic, non-communicable and infectious diseases. The results obtained from clinical trials that make use of gene therapy show ...
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(University of Pretoria, 2016)Background: Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
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(University of Pretoria, 2015)Introduction South Africa is ranked the third most obese country after the United States of America and Great Britain. According to a study conducted by the South African Medical Research Council, 61% of the South African ...
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(University of Pretoria, 2015)Genetic diversity is a well-described concept within many biological disciplines. However, mathematical models determining genetic diversity are often applied within ecological disciplines and are rarely explored within ...
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(University of Pretoria, 2014)Background: Cancer is a crippling disease affecting 32.6 million people globally. It is currently ranked as the leading cause of death worldwide, and is associated with significant morbidity and mortality. Despite advances ...
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(University of Pretoria, 2015)Introduction It is well known that resident adipose stem/stromal cells (ASCs) are a heterogeneous population of multipotent cells characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression ...
Now showing items 1-20 of 48