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Theses and Dissertations (Pharmacology): Recent submissions
Now showing items 1-20 of 95
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(University of Pretoria, 2020)Introduction Breast and prostate cancer mutually represent the most commonly occurring malignancies worldwide in women and men, respectively. The mutative state, recurrence capacity, resistance to conventional chemotherapy, ...
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(University of Pretoria, 2020)Statins, the standard treatment for hypercholesterolaemia, have been associated with side effects, including statin intolerance. This study determined the prevalence of SLCO1B1 single nucleotide variations (SNVs) and ...
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(University of Pretoria, 2020)Anaemia in chronic kidney disease (CKD) mostly results from a decrease in the production of erythropoietin (EPO) by the failing kidney. CKD progression requires treatment with erythropoiesis-stimulating agents and iron ...
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(University of Pretoria, 2020-08)Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. ...
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(University of Pretoria, 2020-07-31)Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality. It is particularly prevalent in people in sub-Saharan Africa, ...
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(University of Pretoria, 2020)Background: Tertiary hospitals have multiple specialist outpatient clinics attended by patients suffering from various comorbid diseases. This results in individuals attending more than one clinic per month, since dedicated ...
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(University of Pretoria, 2019)Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical practice. Poor therapeutic response to medication ...
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(University of Pretoria, 2019)Azathioprine, an immunosuppressant used for many years in the medical sector to maintain long term disease remission in inflammatory bowel disease has a side effect profile that has raised many concerns over the years with ...
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(University of Pretoria, 2019)Introduction: Drugs have been removed from the market for years due to toxicity screening. The highest attrition from the market can be seen by drugs that cause hepatotoxicity. Most drugs are metabolised by phase I cytochrome ...
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(University of Pretoria, 2019)Alongside the recent technology advancements in liquid chromatography (LC) and mass spectrometry (MS) instrumentation there has also been steady progress made with respect to the systematic lipidomic studies of Mycobacterium ...
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(University of Pretoria, 2019)Wounds are a common occurrence and generally heal well within a short time depending on whether tissue needs to be replaced or not. Although there is an understanding of the physiological processes taking place during wound ...
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(University of Pretoria, 2019)Breast cancer is a commonly diagnosed cancer in women, with increasing diagnosis and mortality rates. The triple-negative sub-type of the disease is characterised by lack of hormone-receptor overexpression, exhibition of ...
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(University of Pretoria, 2018)Among several heavy metallic elements, arsenic, cadmium and mercury are most toxic in the environment. These metals are acquired by humans through food and water, which result in severe health related issues. One of the ...
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(University of Pretoria, 2018)Medical conditions which cause morbidity and mortality, such as chronic wounds and infection, lead to significant medical costs. Much of the world's population is dependent on alternative medicine, of which herbal medicine ...
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(University of Pretoria, 2018)Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor-alpha, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The lack of dependence on estrogen by TNBC cells makes ...
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(University of Pretoria, 2018)Introduction Obesity is a growing epidemic not just nationally but worldwide and is responsible for a substantial economic burden in both developed and developing countries. Obesity is a major risk factor for type 2 ...
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(University of Pretoria, 2019)Introduction Medicine regulation and control is not an option but a necessity for national health programmes. In South Africa, a new amended regulation required a review of complementary and alternative medicine (CAMs) ...
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(University of Pretoria, 2018)South Africa has a quadruple burden or disease which leads to increased pharmaceutical expenditure on communicable and non-communicable diseases. This study aimed to determine the proportion of patients that return unused ...
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(University of Pretoria, 2018)Numerous publications outlining the quantitative determination and semi-quantitative screening for both parent and metabolites of the natural plant derived cannabinoids have been reviewed due to the widespread use and abuse ...
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(University of Pretoria, 2018)Introduction: Diabetes mellitus is considered one of the four major non-communicable disease with the global prevalence of this disease nearly doubling over the past 40 years, making it one of the leading causes of morbidity ...
Now showing items 1-20 of 95