• Unraveling the complex interconnection between specific Inflammatory signaling pathways and mechanisms involved in HIV-associated colorectal oncogenesis 

  Damane, Botle Precious; Mulaudzi, Thanyani Victor; Kader, Sayed Shakeel; Naidoo, Pragalathan; Savkovic, Suzana D.; Dlamini, Zodwa; Mkhize-Kwitshana, Zilungile Lynette (MDPI, 2023-02)

  The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, ...
• Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 

  Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)

  Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
• Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 

  Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)

  Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...
• Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 

  Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen Bates; Dlamini, Zodwa (MDPI, 2023-08-07)

  Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
• Renal papillary necrosis (RPN) in an African population : disease patterns, relevant pathways, and management 

  Gaudji, Guy Roger; Bida, M.; Conradie, Marius; Damane, Botle Precious; Bester, Megan (MDPI, 2023-01)

  Renal papillary necrosis (RPN) is characterized by coagulative necrosis of the renal medullary pyramids and papillae. Multiple conditions and toxins are associated with RPN. Several RPN risk factors, or POSTCARDS, have ...
• The impact of colon injuries on the outcome of gunshot wounds to the abdomen 

  Singh, Yonita; Motilall, Sooraj; Khulu, Bongani L.; Jackson, Brandon Spencer (Springer, 2023-08)

  PURPOSE : Factors predicting morbidity and mortality in patients with colon-related gunshot injuries and the management of these injuries are not always straightforward. This aimed to assess the impact of abdominal gunshot ...
• Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 

  Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)

  BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
• Concordance of fine needle aspiration cytology and final histology of salivary gland tumours 

  Ndotora, F.R.; Jackson, Brandon Spencer (Medpharm Publications, 2023)

  BACKGROUND : Fine needle aspiration cytology (FNAC) is a widely used diagnostic tool to evaluate salivary gland tumours. The Milan system for reporting salivary gland cytopathology allows for standardisation and facilitates ...
• Early detection of pancreatic adenocarcinoma 

  Jonas, Eduard; Brand, Martin (Medpharm Publications, 2023)

  No abstract available.
• Point-of-care ultrasound assessment of a swollen limb following snakebite envenomation – an adjunct to avoid fasciotomy 

  Smit, Almien; Lalloo, Vidya; Engelbrecht, Andreas; Mashego, L.D.; Monzon, Barbaro (Medpharm Publications, 2023)

  Acute limb compartment syndrome can occur with cytotoxic snake envenomation. Ultrasound (US) assessment of the affected limb has been suggested as an adjunct to the administration of snakebite polyvalent antivenom to ...
• South African surgical trainees Master of Medicine dissertation survey 

  Barnard, M.; Jackson, Brandon Spencer (Medpharm Publications, 2023)

  BACKGROUND : Since 2011, South African specialist registration requires a research component in the form of a Master of Medicine (MMed) degree. The aim of the study was to assess opinion regarding research and the progression ...
• Surgical exploration for penetrating neck trauma - an audit of results in 145 patients 

  Laher, N.; Monzon-Torres, B.; Mauser, M. (Medpharm Publications, 2023)

  BACKGROUND : Selective non-operative management (SNOM) is the current gold standard for the treatment of patients with penetrating neck trauma. The policy revolves around the liberal use of computed tomography angiography ...
• Do antiseptic coated sutures reduce colo-colonic anastomotic leaks? 

  Elsenbroek, Christiaan F.; Brand, Martin (Sage, 2023-04)

  BACKGROUND : Colorectal anastomotic leaks remain one of the most significant complications following colorectal surgery. Various interventions to reduce anastomotic leaks have been investigated, however few have resulted ...
• Life expectancy of patients with diabetic foot sepsis post-lower extremity amputation at a regional hospital in a South African setting. A retrospective cohort study 

  Mokoala, Thoriso C.; Sididzha, Vhusani; Molefe, Etsumang D.; Luvhengo, Thifhelimbilu E. (Elsevier, 2024-04)

  BACKGROUND : Diabetes foot sepsis (DFS) is the leading cause of amputation of lower extremities. Over 50 % of patients who have had major lower extremity amputation due to DFS are dead within 4 years following the ...
• Adrenal incidentaloma controversial size recommendations 

  Jackson, Brandon Spencer (AVES, 2023-03)

  The size of adrenal incidentalomas has important implications for diagnosis and management. Recommendations from endocrine societies do not all correlate with regard to adrenal incidentaloma size. Therefore, the aim was ...
• Acute pancreatitis - revisiting the clinical basics 

  Govener, T.; Brand, Martin (In House Publications, 2022)

  Acute pancreatitis refers to acute inflammation of the pancreas, usually accompanied by abdominal pain and elevations of serum pancreatic enzymes. This syndrome is usually a discrete episode which causes varying degrees ...
• Characterization of chronic calcific pancreatitis in the presence of HIV infection : comparison with uninfected patients 

  Brand, Martin (In House Publications, 2022)

  Chronic calcific pancreatitis (CP) is a progressive fibro-inflammatory disease of the pancreas. In its later stages it is characterized by both exocrine dysfunction presenting as malabsorption and steatorrhea, and endocrine ...
• Accurate anatomic repair of obstetric anal sphincter damage or rectovaginal fistula aided by prior ultrasonograghy : a cohort study 

  Mokoena, Taole; Abdool, Zeelha (Wolters Kluwer Health, 2023-06)

  BACKGROUND : Anorectal obstetric injuries resulting in anal sphincter damage (ASD) and rectovaginal fistula (RVF) remain a major problem. The resulting flatus or faecal incontinence is devastating. Surgical repair remains ...
• Influence of the microbiome metagenomics and epigenomics on gastric cancer 

  Mathebela, Precious; Damane, Botle Precious; Mulaudzi, Thanyani Victor; Mkhize-Khwitshana, Zilungile Lynette; Gaudji, Guy Roger; Dlamini, Zodwa (MDPI, 2022-11)

  Gastric cancer (GC) is one of the major causes of cancer deaths worldwide. The disease is seldomly detected early and this limits treatment options. Because of its heterogeneous and complex nature, the disease remains ...
• Exploiting the molecular basis of oesophageal cancer for targeted therapies and biomarkers for drug response : guiding clinical decision-making 

  Mbatha, Sikhumbuzo Z.; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-09-22)

  Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality ...

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