Research Articles (Genetics)

Research Articles (Genetics)

 

A collection containing some of the full text peer-reviewed/ refereed articles published by researchers from the Department of Genetics

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  • Van de Peer, Yves; Ngoc, Phuong Cao Thi; Greenhalgh, Robert; Dermauw, Wannes; Rombauts, Stephane; Bajda, Sabina; Zhurov, Vladimir; Grbic, Miodrag; Van Leeuwen, Thomas; Rouze, Pierre (Oxford University Press, 2016-10-26)
    While mechanisms to detoxify plant produced, anti-herbivore compounds have been associated with plant host use by herbivores, less is known about the role of chemosensory perception in their life histories. This is ...
  • Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L.; Cowan, Don A. (Natural Product, 2014-11)
    Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
  • Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L. (Elsevier, 2014-02)
    Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
  • Khazir, Jabeena; Pilcher, Lynne A.; Riley, Darren L.; Islam, Md Ataul; Mir, Bilal Ahmad; Chashoo, Gousia; Saxena, Ajit K.; Kumar, H.M.S. (Halmuthur Mahabalarao Sampath) (Springer, 2016-09)
    Here we describe ring opening reaction of a novel halo triene derivative viz., (3S, 5aS)-8- chloro-3a, 4, 5, 5a-tetrahydro-3, 5a, 9-trimethylnaphtho [1, 2-b] furan-2(3H)-one of α- santonin upon nucleophillic attack with ...
  • Kanzi, Aquillah M.; Musyoka, Thommas M.; Lobb, Kevin A.; Bishop, Özlem Tastan (Taylor and Francis, 2016-01)
    Falcipain-2 (FP-2) and falcipain-3 (FP-3), haemoglobin-degrading enzymes in Plasmodium falciparum, are validated drug targets for the development of effective inhibitors against malaria. However, no commercial drug-targeting ...
  • Coetzee, Martin Petrus Albertus; Govinden-Soulange, J.; Lobine, D.; Frederich, M.; Kodja, H.; Ranghoo-Sanmukhiya, V.M. (Elsevier, 2017-01)
    In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. ...
  • Barnes, Irene; Fraser, S.; Martín-García, J.; Perry, A.; Kabir, M.S.; Owen, T.; Solla, A.; Brown, A.V.; Bulman, L.S.; Hale, M.D.; Vasconcelos, M.W.; Lewis, K.J.; Doğmusı-Lehtijarvi, H.T.; Markovskaja, S.; Woodward, S.; Bradshaw, R.E. (Wiley, 2016-10)
    Dothistroma needle blight (DNB), caused by Dothistroma septosporum and Dothistroma pini, is a highly damaging disease of pine. DNB was originally considered a problem on exotic Pinus radiata plantations in the Southern ...
  • Wall, Gayle V.; Rutkowska, Daria Anna; Mizrachi, Eshchar; Huismans, H. (Henk); Van Staden, Vida (Cambridge University Press, 2017-02)
    The bulk of African horse sickness virus (AHSV) major core protein VP7 self-assembles into flat, hexagonal crystalline particles in a process appearing unrelated to viral replication. Why this unique characteristic of AHSV ...
  • Van Rensburg, Elizabeth J.; Southey, Melissa C.; Goldgar, David E.; Winqvist, Robert; Pylkas, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William D.; Dennis, Joe; Michailidou, Kyriaki; Heikkinen, Tuomas; Nevanlinna, Heli; Hopper, John L.; Dork, Thilo; Claes, Kathleen B.M.; Reis-Filho, Jorge; Teo, Zhi Ling; Radice, Paolo; Catucci, Irene; Peterlongo, Paolo; Tsimiklis, Helen; Odefrey, Fabrice A.; Dowty, James G.; Schmidt, Marjanka K.; Broeks, Annegien; Hogervorst, Frans B.; Verhoef, Senno; Carpenter, Jane; Clarke, Christine; Scott, Rodney J.; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; Dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K.; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Federik; Burwinkel, Barbara; Yang, Rongxi; Guenel, Pascal; Truong, Therese; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig; Nielsen, Sune F.; Flyger, Henrik; Benitez, Javier; Zamora, M. Pilar; Perez, Jose Ignacio Arias; Menendez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan; Ziogas, Argyrios; Clarke, Christina A.; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Brauch, Hiltrud; Bruning, Thomas; Ko, Yon-Dschun; Muranen, Taru A.; Aittomaki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Spurdle, Amanda B.; kConFab Investigators; Australian Ovarian Cancer Study Group; Wauters, Els; Smeets, Dominiek; Beuselinck, Benoit; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Olson, Janet E.; Vachon, Celine; Pankratz, Vernon S.; McLean, Catriona; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Marchand, Loic Le; Kristensen, Vessela; Alnæs, Grethe Grenaker; Zheng, Wei; Hunter, David J.; Lindstrom, Sara; Hankinson, Susan E.; Kraft, Peter; Andrulis, Irene; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Jukkola-Vuorinen, Arja; Grip, Mervi; Kauppila, Saila; Devilee, Peter; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Hollestelle, Antoinette; Garcia-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Eccles, Diana M.; Rafiq, Sajjad; Tapper, William J.; Gerty, Sue M.; Martens, John W.M.; Collee, J. Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Cox, Angela; Reed, Malcolm W.R.; Luccarini, Craig; Baynes, Caroline; Dunning, Alison M.; Hamann, Ute; Torres, Diana; Ulmer, Hans Ulrich; Rudiger, Thomas; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Gonzalez-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Alvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Simard, Jacques; Dumont, Martine; Soucy, Penny; Eeles, Rosalind; Muir, Kenneth; Wiklund, Fredrik; Gronberg, Henrik; Schleutker, Johanna; Nordestgaard, Børge G.; Weischer, Maren; Travis, Ruth C.; Neal, David; Donovan, Jenny L.; Hamdy, Freddie C.; Khaw, Kay-Tee; Stanford, Janet L.; Blot, William J.; Thibodeau, Stephen; Schaid, Daniel J.; Kelley, Joseph L.; Maier, Christiane; Kibel, Adam S.; Cybulski, Cezary; Cannon-Albright, Lisa; Butterbach, Katja; Park, Jong; Kaneva, Radka; Batra, Jyotsna; Teixeira, Manuel R.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Benlloch, Sara; Renner, Stefan P.; Hartmann, Arndt; Hein, Alexander; Ruebner, Matthias; Lambrechts, Diether; Van Nieuwenhuysen, Els; Vergote, Ignace; Lambretchs, Sandrina; Doherty, Jennifer A.; Rossing, Mary Anne; Nickels, Stefan; Eilber, Ursula; Wang-Gohrke, Shan; Odunsi, Kunle; Sucheston-Campbell, Lara E.; Friel, Grace; Lurie, Galina; Killeen, Jeffrey L.; Wilkens, Lynne R.; Goodman, Marc T.; Runnebaum, Ingo; Hillemanns, Peter A.; Pelttari, Liisa M.; Butzow, Ralf; Modugno, Francesmary; Edwards, Robert P.; Ness, Roberta B.; Moysich, Kirsten B.; Du Bois, Andreas; Heitz, Florian; Harter, Philipp; Kommoss, Stefan; Karlan, Beth Y.; Walsh, Christine; Lester, Jenny; Jensen, Allan; Kruger Kjaer, Susanne; Hogdall, Estrid; Peissel, Bernard; Bonanni, Bernardo; Bernard, Loris; Goode, Ellen L.; Fridley, Brooke L.; Vierkant, Robert A.; Cunningham, Julie M.; Larson, Melissa C.; Fogarty, Zachary C.; Kalli, Kimberly R.; Liang, Dong; Lu, Karen H.; Hildebrandt, Michelle A.T.; Wu, Xifeng; Levine, Douglas A.; Dao, Fanny; Bisogna, Maria; Berchuck, Andrew; Iversen, Edwin S.; Marks, Jeffrey R.; Akushevich, Lucy; Cramer, Daniel W.; Schildkraut, Joellen; Terry, Kathryn L.; Poole, Elizabeth M.; Stampfer, Meir; Tworoger, Shelley S.; Bandera, Elisa V.; Orlow, Irene; Olson, Sara H.; Bjorge, Line; Salvesen, Helga B.; Van Altena, Anne M.; Aben, Katja K.H.; Kiemeney, Lambertus A.; Massuger, Leon F.A.G.; Pejovic, Tanja; Bean, Yukie; Brooks-Wilson, Angela; Kelemen, Linda E.; Cook, Linda S.; Le, Nhu D.; Gorski, Bohdan; Gronwald, Jacek; Menkiszak, Janusz; Hogdall, Claus K.; Lundvall, Lene; Nedergaard, Lotte; Engelholm, Svend Aage; Dicks, Ed; Tyrer, Jonathan; Campbell, Ian; McNeish, Iain; Paul, James; Siddiqui, Nadeem; Glasspool, Rosalind; Whittemore, Alice S.; Rothstein, Joseph H.; McGuire, Valerie; Sieh, Weiva; Cai, Hui; Shu, Xiao-Ou; Teten, Rachel T.; Sutphen, Rebecca; McLaughlin, John R.; Narod, Steven A.; Phelan, Catherine M.; Monteiro, Alvaro N.; Fenstermacher, David; Lin, Hui-Yi; Permuth, Jennifer B.; Sellers, Thomas A.; Chen, Y. Ann; Tsai, Ya-Yu; Chen, Zhihua; Gentry-Maharaj, Aleksandra; Gayther, Simon A.; Ramus, Susan J.; Menon, Usha; Wu, Anna H.; Pearce, Celeste L.; Van Den Berg, David; Pike, Malcolm C.; Dansonka-Mieszkowska, Agnieszka; Plisiecka-Halasa, Joanna; Moes-Sosnowska, Joanna; Kupryjanczyk, Jolanta; Pharoah, Paul D.P.; Song, Honglin; Winship, Ingrid; Chenevix-Trench, Georgia; Giles, Graham G.; Tavtigian, Sean V.; Easton, Doug F.; Milne, Roger L. (Elsevier, 2016-09-05)
    BACKGROUND The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations ...
  • Coetzee, Martin Petrus Albertus; Denman, Sandra; Barrett, Glyn; Kirk, Susan A.; McDonald, James E. (Oxford University Press, 2017-01)
    The identity of 51 isolates of Armillaria from 15 Quercus robur trees in poor health, and a single healthy tree, at nine sites in England, was determined using multilocus sequence analysis (MLSA) of three gene regions. ...
  • Van Rensburg, Elizabeth J.; Rebbeck, Timothy R.; Friebel, Tara M.; Mitra, Nandita; Wan, Fei; Chen, Stephanie; Andrulis, Irene L.; Apostolou, Paraskevi; Arnold, Norbert; Arun, Banu K.; Barrowdale, Daniel; Benitez, Javier; Berger, Raanan; Berthet, Pascaline; Borg, Ake; Buys, Saundra S.; Carter, Jonathan; Chiquette, Jocelyne; Claes, Kathleen B.M.; Couch, Fergus J.; Cybulski, Cezary; Daly, Mary B.; De la Hoya, Miguel; Diez, Orland; Domchek, Susan M.; Nathanson, Katherine L.; Durda, Katarzyna; Ellis, Steve; EMBRACE; Evans, D. Gareth; Foretova, Lenka; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; Glendon, Gord; Godwin, Andrew K.; Greene, Mark H.; Gronwald, Jacek; Hahnen, Eric; Hallberg, Emily; Hamann, Ute; Hansen, Thomas V.O.; HEBON; Imyanitov, Evgeny N.; Isaacs, Claudine; Jakubowska, Anna; Janavicius, Ramunas; Jaworska-Bieniek, Katarzyna; John, Esther M.; Karlan, Beth Y.; Kaufman, Bella; KConFab investigators; Kwong, Ava; Laitman, Yael; Lasset, Christine; Lazaro, Conxi; Lester, Jenny; Loman, Niklas; Lubinski, Jan; Manoukian, Siranoush; Mitchell, Gillian; Montagna, Marco; Neuhausen, Susan L.; Nevanlinna, Heli; Niederacher, Dieter; Nussbaum, Robert L.; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Park, Sue Kyung; Piedmonte, Marion; Radice, Paolo; Rappaport-Fuerhauser, Christine; Rookus, Matti A.; Seynaeve, Caroline; Simard, Jacques; Singer, Christian F.; Soucy, Penny; Southey, Melissa; Stoppa-Lyonnet, Dominique; Sukiennicki, Grzegorz; Szabo, Csilla I.; Tancredi, Mariella; Teixeira, Manuel R.; Teo, Soo-Hwang; Terry, Mary Beth; Thomassen, Mads; Tihomirova, Laima; Tischkowitz, Marc; Toland, Amanda Ewart; Toloczko-Grabarek, Aleksandra; Tung, Nadine; Villano, Danylo; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weitzel, Jeffrey N.; Zidan, Jamal; Zorn, Kristin K.; McGuffog, Lesley; Easton, Douglas; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Ramus, Susan J. (BioMed Central, 2016-11-11)
    BACKGROUND : Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences ...
  • Zablocki, Olivier; Cowan, Don A.; Rybicki, E.P. (American Phytopathological Society, 2014-12)
    Chlorotic, streak-like symptoms were observed in April 2013 on a single specimen of Albuca rautanenii (Schinz) J.C.Manning & Goldblatt (Family: Hyacinthaceae) found among other plants near Homeb in the Namib Desert, ...
  • Johnson, Riegardt M.; Ramond, Jean-Baptiste; Gunnigle, Eoin; Cowan, Don A.; Seely, Mary (Springer, 2017-01)
    The central Namib Desert is hyperarid, where limited plant growth ensures that biogeochemical processes are largely driven by microbial populations. Recent research has shown that niche partitioning is critically involved ...
  • Gunnigle, Eoin; Frossard, Aline; Ramond, Jean-Baptiste; Guerrero, Leandro D.; Cowan, Don A.; Seely, Mary (Nature Publishing Group, 2017-01-10)
    Microbes in hot desert soil partake in core ecosystem processes e.g., biogeochemical cycling of carbon. Nevertheless, there is still a fundamental lack of insights regarding short-term (i.e., over a 24-hour [diel] cycle) ...
  • Marchal, Kathleen; Van de Peer, Yves; Yao, Yao; Storme, Veronique (PeerJ, 2016-12-21)
    We developed a bio-inspired robot controller combining an artificial genome with an agent-based control system. The genome encodes a gene regulatory network (GRN) that is switched on by environmental cues and, following ...
  • Cowan, Don A.; Van Zyl, Leonardo Joaquim; Nemavhulani, Shonisani; Cass, James; Trindade, Marla (BioMed Central, 2016-12-03)
    BACKGROUND : Soda lakes are unique environments in terms of their physical characteristics and the biology they harbour. Although well studied with respect to their microbial composition, their viral compositions have ...
  • Coetzee, Martin Petrus Albertus; Kinge, T.R.; Mih, A.M. (CSIRO, 2012)
    Ganoderma is an important genus of the Polyporales in the tropics. Identification of tropical species has mainly been based on morphology, which has led to misidentification. This study aimed to elucidate the diversity ...
  • Bihon, Wubetu; Slippers, Bernard; Wingfield, Michael J.; Wingfield, Brenda D.; Burgess, Treena (Springer, 2012-01)
    Introduced populations of organisms typically have reduced diversity compared to those that are native. It is, therefore, unusual that introduced populations of the fungal tree pathogen Diplodia pinea have been shown ...
  • Greeff, Jaco M. (Jacobus Maree); Greeff, Francois A.; Greeff, Andre S.; Rinken, Lucas; Welgemoed, Dawid J.; Harris, Yolanda (Elsevier, 2012-07)
    Extrapair paternity is a crucial parameter for evolutionary explanations of reproductive behavior. Early studies and human testis size suggest that human males secure/suffer frequent extrapair paternity. If these high ...
  • Cowan, Don A.; De Maayer, Pieter (BioMed Central, 2016-11-14)
    BACKGROUND : Protein glycosylation involves the post-translational attachment of sugar chains to target proteins and has been observed in all three domains of life. Post-translational glycosylation of flagellin, the main ...

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