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Browsing Health Sciences by Author "Bester, Janette"
Now showing items 1-20 of 22
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Pretorius, Etheresia; Mbotwe, Sthembile; Bester, Janette; Robinson, Christopher J.; Kell, Douglas B. (The Royal Society, 2016)It is well known that a variety of inflammatory diseases are accompanied by hypercoagulability, and a number of more-or-less longer-term signalling pathways have been shown to be involved. In recent work, we have suggested ...
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Pretorius, Etheresia; Vermeulen, Natasha; Bester, Janette (Informa Healthcare, 2014-06)Prothrombin mutation G20210A, anti-phospholipid syndrome as well as iron overload has previously been shown to cause thrombotic events. The main reason for this is the involvement of these anomalies in causing ...
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Pretorius, Etheresia; Bester, Janette; Kell, Douglas B. (IOS Press (open access), 2016-06)The progression of Alzheimer’s disease (AD) is accompanied by a great many observable changes, both molecular and physiological. These include oxidative stress, neuroinflammation, and (more proximal to cognitive decline) ...
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Nielsen, Vance G.; Pretorius, Etheresia; Bester, Janette; Jacobsen, Wayne K.; Boyle, Patrick K.; Reinhard, Joao P. (Bentham Science, 2015-01)Alzheimer’s disease (AD) is a significant source of morbidity and mortality for millions of people worldwide, and multiple potential etiologies have been postulated to contribute to AD. Among these, spontaneous cerebral ...
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Potgieter, Marnie; Bester, Janette; Kell, Douglas B.; Pretorius, Etheresia (Oxford University Press, 2015-07)Blood in healthy organisms is seen as a ‘sterile’ environment: it lacks proliferating microbes. Dormant or not-immediately-culturable forms are not absent, however, as intracellular dormancy is well established. We highlight ...
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Strydom, Morne A.; Bester, Janette; Mbotwe, Sthembile; Pretorius, Etheresia (Nature Publishing Group, 2016-10-24)A significant burden of illness is caused globally by snakebites particularly by the puff adder, Bitis arietans. Presently there is no reliable and rapid method to confirm envenomation on blood chemistry; although ...
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Bester, Janette; Pretorius, Etheresia (Nature Publishing Group, 2016-08-26)Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory ...
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Chamboko, Tanyaradzwa Dellah; Love, Jenna; Strydom, Morne; Bester, Janette (Elsevier, 2024-01)BACKGROUND : Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra (Naja mossambica) is found in Sub-Saharan African countries, and its venom ...
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Phasha, Marry-Ann Ntanyane; Soma, Prashilla; Bester, Janette; Pretorius, E.; Phulukdaree, Alisa (Elsevier, 2022-08)Factor XIII, a transglutaminase that plays a crucial role in clot formation, consists of subunits A and B. Single nucleotide polymorphisms in Factor XIII-A have been linked to thrombotic risk. In Type 2 Diabetes mellitus ...
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Bester, Janette; Buys, A.V. (Antonia Vergina); Lipinski, Boguslaw; Kell, Douglas B.; Pretorius, Etheresia (Frontiers Research Foundation, 2013-12-06)INTRODUCTION: Unliganded iron both contributes to the pathology of Alzheimer's disease (AD) and also changes the morphology of erythrocytes (RBCs). We tested the hypothesis that these two facts might be linked, i.e., that ...
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Page, Martin J.; Bester, Janette; Pretorius, Etheresia (Nature Publishing Group, 2018-01-29)Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known proinflammatory molecules. When TNF-α is upregulated, it contributes to changes in coagulation and causes C3 induction. They both interact ...
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De Villiers, Sulette; Swanepoel, A.C. (Albe Carina); Bester, Janette; Pretorius, Etheresia (Japan Atherosclerosis Society, 2016)Central to the pathogenesis of ischaemic stroke are the normally protective processes of platelet adhesion and activation. Experimental evidence has shown that the ligand-receptor interactions in ischaemic stroke represent ...
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Morris, Chanel; Potgieter, Johan C.; Bester, Janette (Sage, 2023)BACKGROUND : Haemophilia A (HA) is a bleeding disorder, due to a deficiency in factor VIII (FVIII). These patients are unable to produce a stable fibrin clot in the propagation phase of coagulation as they do not generate ...
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Pretorius, Etheresia; Bester, Janette; Vermeulen, Natasha; Alummoottil, Sajee; Soma, Prashilla; Buys, A.V. (Antonia Vergina); Kell, Douglas B. (BioMed Central, 2015-03)We have noted in previous work, in a variety of inflammatory diseases, where iron dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape and to adopt a skewed morphology (as judged ...
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De Villiers, Sulette; Bester, Janette; Kell, Douglas B.; Pretorius, Etheresia (Frontiers Media, 2019-11-26)INTRODUCTION : Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised ...
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Pretorius, Etheresia; Bester, Janette; Page, Martin J.; Kell, Douglas B. (Frontiers Media, 2018-08-22)Many studies indicate that there is a (mainly dormant) microbial component in the progressive development of Alzheimer-type dementias (ADs); and that in the case of Gram-negative organisms, a chief culprit might be the ...
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Pretorius, Etheresia; Bester, Janette; Vermeulen, Natasha; Lipinski, Boguslaw; Gericke, George S.; Kell, Douglas B. (Public Library of Science, 2014-01-09)It is well-known that individuals with increased iron levels are more prone to thrombotic diseases, mainly due to the presence of unliganded iron, and thereby the increased production of hydroxyl radicals. It is also known ...
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Alummoottil, Sajee; Van Rooy, Mia-Jeanne; Bester, Janette; Grobbelaar, C.W. (Craig); Phulukdaree, Alisa (MDPI, 2023-03)BACKGROUND : Non-communicable diseases are often associated with chronic inflammation, placing patients suffering from these conditions at a higher risk of thrombosis and other complications. The pathophysiology of asthma ...
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Swanepoel, A.C. (Albe Carina); Bester, Janette; Emmerson, Odette; Soma, Prashilla; Beukes, Derylize; Van Reenen, Mari; Loots, Du Toit; Du Preez, Ilse (Mary Ann Liebert, 2020-07)The association between hypercoagulability and use of drospirenone (DRSP) and ethinylestradiol (EE) containing combined oral contraceptives (COCs) is an important clinical concern. We have previously reported that the ...
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Soma, Prashilla; Swanepoel, A.C. (Albe Carina); Bester, Janette; Pretorius, Etheresia (Springer, 2017-05)INTRODUCTION : Type 2 diabetes mellitus is a pandemic associated with disturbance inhaemostasis that could contribute to the development of diabetic vascular disease and accelerated atherosclerosis. In this population, ...
Now showing items 1-20 of 22