dc.contributor.author |
Gray, Meeghan E.
|
|
dc.contributor.author |
Thain, David S.
|
|
dc.contributor.author |
Cameron, Elissa Z.
|
|
dc.contributor.author |
Miller, Lowell A.
|
|
dc.date.accessioned |
2011-08-03T07:17:20Z |
|
dc.date.available |
2011-08-03T07:17:20Z |
|
dc.date.issued |
2010-10 |
|
dc.description.abstract |
CONTEXT: Contraception is increasingly used as a management technique to reduce fertility in wildlife populations, but the feasibility of contraceptive formulations has been limited until recently as they have required multiple treatments to achieve prolonged infertility. AIMS: We tested the efficacy and evaluated potential side effects of two contraceptive formulations, a porcine zona pellucida (PZP) formulation, SpayVac®, and a gonadotrophin releasing hormone (GnRH) formulation GonaCon-B™, in a population of free-roaming feral horses (Equus caballus). Both formulations were developed to provide several years of infertility with one injection. METHODS: Females were treated in June 2005 with either GonaCon-B™ (n=24), SpayVac® (n=20), adjuvant only (n=22), or received no injection (n=18). Females were monitored for fertility status year round for three years post treatment. KEY RESULTS: Both contraceptive treatments significantly reduced fertility for three years. Fertility rates for GonaCon-B™ mares were 39%, 42% and 31% respectively and 37%, 50%, and 44% for SpayVac® mares. During the same seasons, 61%, 67% and 76% of control females were fertile. We found no significant effects from contraceptive treatment on the sex ratio of foals, birthing season, or foal survival. CONCLUSIONS: These results demonstrate that both vaccines are capable of significantly reducing fertility for several years without boosters. IMPLICATIONS: Contraceptive vaccines examined in this study represent a useful tool for the management of feral horses, due to their being efficacious for three years in the absence of booster immunisations |
en |
dc.description.sponsorship |
This research was funded by grants from the Nevada Arid Rangeland Initiative
NOA15353CG, 110615253BS, 140115253BS, 140215253BS, Hatch Grant 13215353BS
and a research grant from the Animal Behavior Society. |
en_US |
dc.description.uri |
www.publish.csiro.au/journals/wr |
en_US |
dc.identifier.citation |
Gray, ME, Train, DS, Cameron, EZ & Miller, LA 2010, 'Multi-year fertility reduction in free-roaming feral horses with single injection', Wildlife Research, vol. 37, no. 6, pp. 457-481. |
en |
dc.identifier.issn |
1035-3712 (print) |
|
dc.identifier.issn |
1448-5494 (online) |
|
dc.identifier.other |
10.1071/WR09175 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/16988 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
CSIRO |
en_US |
dc.rights |
© CSIRO 2011 |
en_US |
dc.subject |
GnRH vaccine |
en |
dc.subject |
Immunocontraception |
en |
dc.subject |
Population control |
en |
dc.subject |
PZP vaccine |
en |
dc.subject.lcsh |
Contraception, Immunological |
en |
dc.subject.lcsh |
Animal contraception -- Fieldwork |
en |
dc.subject.lcsh |
Contraceptives -- Side effects |
en |
dc.subject.lcsh |
Wild horses |
en |
dc.subject.lcsh |
Feral mammals |
en |
dc.subject.lcsh |
Contraceptive drugs, Injectable -- Side effects |
en |
dc.subject.lcsh |
Fertility -- Effect of drugs on |
en |
dc.title |
Multi-year fertility reduction in free-roaming feral horses with single injection immunocontraceptive formulations |
en |
dc.type |
Postprint Article |
en |