The treatment of cholesterol : issues, effects and targets

Ker, James A.

dc.contributor.author	Ker, James A.
dc.date.accessioned	2011-04-05T10:07:41Z
dc.date.available	2011-04-05T10:07:41Z
dc.date.issued	2010-11
dc.description.abstract	Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. The end result is a significant reduction in cholesterol levels, and a consequent significant reduction in mortality and cardiovascular events in the appropriate individual.	en_US
dc.identifier.citation	Ker, JA 2010, 'The treatment of cholesterol : issues, effects and targets', South African Family Practice, vol. 52, no. 6, pp. 523-524. [http;//www.safpj.co.za]	en_US
dc.identifier.issn	1726-426X (online)
dc.identifier.issn	1026-9177 (print)
dc.identifier.uri	http://hdl.handle.net/2263/16212
dc.language.iso	en	en_US
dc.publisher	South African Academy of Family Practice/Primary Care	en_US
dc.rights	© SAAFP	en_US
dc.subject	Cholesterol	en_US
dc.subject	Hypercholesterolemia	en_US
dc.subject	Treatment	en_US
dc.subject	Drug therapy	en_US
dc.subject	Statins	en_US
dc.subject	Effectivity	en_US
dc.subject	LDL cholesterol	en_US
dc.subject	Target	en_US
dc.subject	Risk	en_US
dc.subject	Prevention	en_US
dc.subject	Elderly	en_US
dc.subject	Time factors	en_US
dc.subject	Atherosclerosis	en_US
dc.subject	Safety	en_US
dc.subject.lcsh	Cholesterol -- Treatment
dc.title	The treatment of cholesterol : issues, effects and targets	en_US
dc.type	Article	en_US