Combretum stylesii O.Maurin, Jordaan & A.E.van Wyk, a liana or slender tree with scrambling branches from the Tugela River Valley
(KwaZulu-Natal), South Africa, is described. Molecular data supports its placement in subgenus Combretum section Ciliatipetala with its closest
relative Combretum edwardsii. The new species differs from C. edwardsii in having, amongst others, a single mature leaf form, leaves softly
textured, with whitish hairs, often with drooping habit, shorter leaf petioles (less than 5 mm), and less complex 8-celled leaf scales. A key to the species and infraspecific taxa of section Ciliatipetala in the Flora of southern Africa region is provided.