• Investigating the role of oxidative stress in apoptosis induced by a sulphamoylated estradiol analogue in breast cell lines 

  Lebelo, Maphuti Tebogo (University of Pretoria, 2020)

  2-Methoxyestradiol (2ME), a 17β-estradiol metabolite, exerts anticancer properties however, the compound was found to possess low bioavailability. This resulted in the in silico-design of 2ME analogues with a sulphamoyl ...
• Investigating lipopolysaccharide-induced inflammation in Sprague-Dawley rats on liver function with specific focus on coagulation factor production 

  Rathebe, Karabo (University of Pretoria, 2023)

  Neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), have long confounded the scientific and medical communities. The extensive research into these diseases, particularly AD has produced ...
• Association between head circumference and monocyte phenotype in neonates exposed and unexposed to HIV at Kalafong Provincial Tertiary Hospital 

  Sipsma, Iwan (University of Pretoria, 2023)

  It is well documented that children living with human immunodeficiency virus (HIV) do not perform as well as children not living with HIV on general cognitive tests, processing speed, and visual-spatial tasks, and are at ...
• Neopterin and neurophysiological measurements as markers of anxiety and stress 

  Cronje, Rouxzan (University of Pretoria, 2023)

  Background: Mental health is an increasing global crisis. It has large social, economic, and health costs, with stress and anxiety disorders accounting for a large portion of the impact. Biomarkers may help to improve the ...
• Investigation of the expression of pro-angiogenic markers in cutaneous tumours in vivo and in vitro 

  Nonxuba, Masibulele (University of Pretoria, 2023)

  Cutaneous tumours are common types of cancers that develop from the skin and account for 40% of the cases worldwide. In particular, melanomas and cutaneous haemangiomas are commonly occurring skin tumours that are characterised ...
• The epidemiology and associated risk factors for muscle strain injuries in endurance athletes 

  Kroon, Lize (University of Pretoria, 2023)

  Long-distance running continues to increase in popularity owing to its easy accessibility and people’s growing interest in disease prevention. Over the last 25 years, increasing participation in long-distance has been ...
• Assessing the role of the KISS1 receptor in breast cancer cell behaviour with the use of CRISPR-mediated gene editing 

  Marais, Alex Leah (University of Pretoria, 2023-03-03)

  The recent advancements in gene editing have provided scientists with a powerful tool for the investigation of the role of individual proteins in cellular physiology and disease. Gene editing was preceded by another powerful ...
• Evaluation of a strategy based on multi-drug targeting of cancer proteins in breast cancer cell lines 

  Nortje, Evangeline (University of Pretoria, 2020)

  Therapeutic inefficacy of conventional cancer treatment is a particular dilemma associated with metastatic triple negative breast cancer (TNBC), with patients still facing poor prognosis. The design and development of novel ...
• In vitro induction of the apoptotic intrinsic pathway via a new antimitotic agent 

  Wolmarans, Elize (University of Pretoria, 2014)

  Unique, in silico-designed compounds with possible anticancer properties were identified in our laboratory. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16), with potential carbonic anhydrase IX inhibiting activity, ...
• The association of methylglyoxal-adducts with kinetics and ultrastructure of fibrin clots in coronary artery disease patients with type 2 diabetes mellitus 

  Nxumalo, Mikateko (University of Pretoria, 2020-12-15)

  Background: Glycation influences the ultrastructure and clot kinetics of fibrin clots due to the post-translational modifications in fibrinogen. Methylglyoxal (MG) is used to measure the level of glycation which has been ...
• The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration. 

  Azubuike, Udochi Felicia (University of Pretoria, 2021-02-10)

  Kisspeptin receptor, also known as KISS1R, is the endogenous receptor for the ligand peptide, kisspeptin. It is a G-protein coupled receptor that couples through the Gαq/11 pathway. It has been shown that KISS1R activation ...
• Training load and athlete well-being in university female hockey players during a congested tournament 

  Swan, Justin (University of Pretoria, 2020)

  The monitoring of athlete workload is common practice within field-based team sports. Athlete monitoring is performed using both objective and subjective monitoring tools. Results from previous research investigating the ...
• Effects of gold nanoparticles on vascular endothelial growth factor-A-induced melanoma cell growth and angiogenesis 

  Matutule, Lebogang Johanna (University of Pretoria, 2020-11)

  Melanoma is a skin cancer that relies on angiogenesis for growth and progression. Angiogenesis is the growth of new vessels from existing vessels and follows a number of steps that include endothelial cell growth, migration ...
• The epidemiology and associated risk factors for Achilles tendon overuse running injuries in the Two Oceans Marathon 

  Young, Jonah Dylan (University of Pretoria, 2020)

  Distance running is an effective, low-cost training modality known to improve endurance capacity and cardiovascular health that is accessible to both the competitive and the novice athlete. The accessibility of running has ...
• The Association Of Risk Markers And The Prevalence Of Exercise Associated Muscle Cramps In Distance Runners 

  De Jager, Izaan (University of Pretoria, 2020)

  Title: The Association Of Risk Markers And The Prevalence Of Exercise Associated Muscle Cramps In Distance Runners Candidate: Izaan de Jager Promoter: Prof. MP Schwellnus Co-promoter: Dr. E Korkie Degree: MSc Sports ...
• The prevalence of sleep apnea in patients with Cushing's syndrome 

  Groenewald, Liechka (University of Pretoria, 2020)

  Patients with Cushing’s syndrome often complain about sleep disruption and excessive day time sleepiness, which could contribute to worsening quality of life and metabolic comorbidities (obesity, hypertension, diabetes ...
• The relationships between changes in well-being scores and physical performance test scores in student soccer players 

  Maluleke, Bhekumuzi (University of Pretoria, 2019)

  Maximum physical performance tests appear to best reflect athletes’ training status and readiness to perform; however, it is unfeasible for practitioners to implement physical performance tests while trying to minimise the ...
• Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines 

  Gwangwa, Mokgadi Violet (University of Pretoria, 2019)

  Tumourigenic cells utilize aberrant metabolic process that supports the biosynthetic requirements for hyperproliferation, survival and prolonged maintenance characterised by glucose metabolism to lactate dehydrogenase ...
• Oxygen deprivation state as a marker for the severity of obstructive sleep apnea 

  Janse van Nieuwenhuizen, Juan Lodiwicus (University of Pretoria, 2020)

  Introduction Sleep apnea is classified as a sleep disorder characterized by a complete cessation, known as apneas, or impairment (partial cessation) of breathing, known as hypopneas. During obstructive sleep apnea (OSA), ...
• Development of a breast cancer spheroid model for use in drug discovery and cancer biology research 

  Jurgens, Tamarin (University of Pretoria, 2020)

  The screening of lead compounds during cancer drug discovery still results in many hits that never reach the clinic. This is in part due to the distance between 2D cell culture, which is mostly used for screening assays ...

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